ID   TM168_RAT               Reviewed;         697 AA.
AC   Q5PQM0;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Transmembrane protein 168;
GN   Name=Tmem168;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PROTEIN SEQUENCE OF 125-134, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=Sprague-Dawley; TISSUE=Brain;
RA   Lubec G., Kang S.U.;
RL   Submitted (JUL-2007) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMEM168 family. {ECO:0000305}.
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DR   EMBL; BC087124; AAH87124.1; -; mRNA.
DR   RefSeq; NP_001014076.1; NM_001014054.1.
DR   RefSeq; XP_017448099.1; XM_017592610.1.
DR   AlphaFoldDB; Q5PQM0; -.
DR   STRING; 10116.ENSRNOP00000009450; -.
DR   GlyGen; Q5PQM0; 4 sites.
DR   iPTMnet; Q5PQM0; -.
DR   PhosphoSitePlus; Q5PQM0; -.
DR   PaxDb; Q5PQM0; -.
DR   Ensembl; ENSRNOT00000084531; ENSRNOP00000069933; ENSRNOG00000057290.
DR   GeneID; 312135; -.
DR   KEGG; rno:312135; -.
DR   UCSC; RGD:1307778; rat.
DR   CTD; 64418; -.
DR   RGD; 1307778; Tmem168.
DR   eggNOG; ENOG502QRB6; Eukaryota.
DR   GeneTree; ENSGT00390000005941; -.
DR   InParanoid; Q5PQM0; -.
DR   OrthoDB; 619817at2759; -.
DR   PhylomeDB; Q5PQM0; -.
DR   TreeFam; TF328518; -.
DR   PRO; PR:Q5PQM0; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR029713; TMEM168.
DR   PANTHER; PTHR14437; PTHR14437; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Glycoprotein; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..697
FT                   /note="Transmembrane protein 168"
FT                   /id="PRO_0000284633"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        63..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        223..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        265..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        293..313
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        352..372
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        380..400
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        646..666
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        111
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        337
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        533
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        598
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   697 AA;  79772 MW;  42A50B5F1DF05DF9 CRC64;
     MCKSLRYCFS HCLYLAMTRL EEVNREVNMH SSVRYLGYLA RFNLLVAICL GLYVRWEKTA
     NSLILVIFIL GLFVLGIASI LYYYFSMEAA SLSLSNLWFG FLLGLLCFLD NSSFKSDVKE
     ETTKYLLLTS IVLRILCALV ERLSGYVRHR PTLLTTVEFL ELVGFAIAST TMLVERSLSV
     ILLVMALAML IIDLRMKSFL AIPNLIIFSV LLFFSSLETP QNPIAFACFF ICLITDPFLD
     IYFSGLSVTE RWKPFLYRGR ICRRLSVVFT GMIELTFFTL SAFKLRDTHL WYFVIPGFSI
     FGIFWMICHI IFLLTLWGFH TKLNDCHKVY INHRADNNSL DRIMASKGMR HFCLISEQLV
     FFSLLATAIL GAVSWQPTNG IFLSMFLIVL PLESMAHGLF HELGNCLGGT SVGYAIVIPT
     NFCSPDGQPT LLPPEHVQEL NLRSTGMLNA IQRFFAYHMI ETYGCDYSTS GLSFDTLHSK
     LKAFLELRTV DGPRHDTYVL YYSGHTHGSG EWALAGGDIL RLDTLLEWWR EKNGSFCSRL
     IIILDSENST PWVKEVRKIN DQYVAVQGAE LAKTVDIEEA DPPQLGDFTR DWVEYNCNST
     NNICWTEKGR TVKAMYGVSK RWSDYTLHLP TGSDVAKHWM LHFPRITYPL VHLANWLCGL
     NLFWMCKACF RCLKRLKMSW FLPTVLDTGQ GFKLVKS