ID   TM168_XENLA             Reviewed;         700 AA.
AC   Q7ZY86;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=Transmembrane protein 168;
GN   Name=tmem168;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMEM168 family. {ECO:0000305}.
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DR   EMBL; BC043897; AAH43897.1; -; mRNA.
DR   RefSeq; NP_001080848.1; NM_001087379.1.
DR   AlphaFoldDB; Q7ZY86; -.
DR   DNASU; 380542; -.
DR   GeneID; 380542; -.
DR   KEGG; xla:380542; -.
DR   CTD; 380542; -.
DR   Xenbase; XB-GENE-982332; tmem168.S.
DR   OrthoDB; 619817at2759; -.
DR   Proteomes; UP000186698; Chromosome 3S.
DR   Bgee; 380542; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR029713; TMEM168.
DR   PANTHER; PTHR14437; PTHR14437; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..700
FT                   /note="Transmembrane protein 168"
FT                   /id="PRO_0000284635"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        63..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        171..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        231..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        297..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        355..375
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        383..403
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        340
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        536
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        607
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   700 AA;  79923 MW;  BFF33908C15245EE CRC64;
     MCRSLRYCVS HCLYTAMTRL EEANREVNMY SSVRYLGYLA QLSLLVAICM GLYVRWDQTD
     DSFILVIFIL GLVIFAIASI LYYYFSMEAA SLSLCNLWFG FLLGLLCFID SSTFQHDLKE
     EATKYLLVSS IIIKTLSALV ERICGCVRHR PTLLTSSEFL ELVGFAIAST IMLMQKSLSI
     ILLVAALAMI IIDLRMKSFL SIAILVVFAS LTPELFFRSL DIPVNPYALS CFFFCIISNP
     FLDVYFSGLS VTERWKPYLY RGRFCRRFSV ISIGLIELVF FVFAALKLGD LHLWYFVIPG
     FSIFGIFWLI CHIIFLITLW GFNTKLNECH KVYSTHRPDN NSLDRVMASK GMRHFCLISE
     RLVFFSLLAT IILGAVSWQS SNGLFISIFL IVLPLESMAH GLFHELGNCL GGTSIGYAVV
     IPTNFCSPNG QPMLLPPEHV EELNLRSTGM LNSIQRFFAS HMIETYGCDY STSGLNFDTL
     HSKLKSFLDL RTSDGPRHDT YIIYYTGHSH STGEWALAGG ETLRFETLLE WWREKNGSFC
     SRLIIVLDTE SSQPWVKEVR RVGDQYVAVQ GAEMARVVDI EEADPPQLGD FTKEWVEYNC
     NPDNNINWTE KGRTVKAVYA VSKPWSDYTL HLPTGNDVTK HWMTYFPHIT YPLVHLANWC
     GALNMFWLCK ICYKCLKRLK MNWFLPAVLD TGQGFKLVKS