ID   TM169_BOVIN             Reviewed;         297 AA.
AC   Q2TBG9;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Transmembrane protein 169;
GN   Name=TMEM169;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; BC110238; AAI10239.1; -; mRNA.
DR   RefSeq; NP_001033779.1; NM_001038690.2.
DR   RefSeq; XP_005202845.1; XM_005202788.2.
DR   RefSeq; XP_005202846.1; XM_005202789.2.
DR   RefSeq; XP_010800594.1; XM_010802292.1.
DR   AlphaFoldDB; Q2TBG9; -.
DR   STRING; 9913.ENSBTAP00000013741; -.
DR   PaxDb; Q2TBG9; -.
DR   Ensembl; ENSBTAT00000013741; ENSBTAP00000013741; ENSBTAG00000010413.
DR   GeneID; 617045; -.
DR   KEGG; bta:617045; -.
DR   CTD; 92691; -.
DR   VEuPathDB; HostDB:ENSBTAG00000010413; -.
DR   VGNC; VGNC:35994; TMEM169.
DR   eggNOG; ENOG502QUD9; Eukaryota.
DR   GeneTree; ENSGT00390000015276; -.
DR   HOGENOM; CLU_082140_0_0_1; -.
DR   InParanoid; Q2TBG9; -.
DR   OMA; AFSEWWQ; -.
DR   TreeFam; TF323682; -.
DR   Proteomes; UP000009136; Chromosome 2.
DR   Bgee; ENSBTAG00000010413; Expressed in semen and 74 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR029386; TMEM169.
DR   PANTHER; PTHR31777; PTHR31777; 1.
DR   Pfam; PF15052; TMEM169; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..297
FT                   /note="Transmembrane protein 169"
FT                   /id="PRO_0000271038"
FT   TOPO_DOM        1..159
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        181..210
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        232..297
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   REGION          1..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        47..62
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        63..84
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   297 AA;  33288 MW;  66DA58DD043D28AC CRC64;
     MEEPALVEGQ SQLPSPHHNS LRKAMAAALV LDGESTMGRR KKKKKESRPE SIIIYRSESE
     TLDEEPGESE GGDQPKEEEG DDFIDYPMDD GVWNVPVDSR YVTLTGTITR GKKKGQMVDI
     HVTLTEKELQ ELTKPKASSR ETTPGGRKAC QLGADRGPHV VLWTLVCLPV VFLLSFVVSF
     YYGTITWYNI FLVYNEERTF WHKISCCPCL ILCYPVLIMA MASSLGLYAA VVQLSWSWEA
     WWQAARDMEK GFCGWLCSKL GLEDCSPYSI VELLESDNIS GNLSNKDATQ EIETSAV