TM169_HUMAN
ID TM169_HUMAN Reviewed; 297 AA.
AC Q96HH4; B2R8W6;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Transmembrane protein 169;
GN Name=TMEM169;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Retina;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AK091582; BAC03700.1; -; mRNA.
DR EMBL; AK313536; BAG36313.1; -; mRNA.
DR EMBL; CR933667; CAI45964.1; -; mRNA.
DR EMBL; AC010686; AAY14658.1; -; Genomic_DNA.
DR EMBL; CH471063; EAW70559.1; -; Genomic_DNA.
DR EMBL; BC008604; AAH08604.1; -; mRNA.
DR CCDS; CCDS2401.1; -.
DR RefSeq; NP_001135782.1; NM_001142310.1.
DR RefSeq; NP_001135783.1; NM_001142311.1.
DR RefSeq; NP_001135784.1; NM_001142312.1.
DR RefSeq; NP_612399.1; NM_138390.3.
DR RefSeq; XP_006712914.1; XM_006712851.1.
DR RefSeq; XP_011510475.1; XM_011512173.2.
DR AlphaFoldDB; Q96HH4; -.
DR BioGRID; 124968; 95.
DR STRING; 9606.ENSP00000412524; -.
DR iPTMnet; Q96HH4; -.
DR PhosphoSitePlus; Q96HH4; -.
DR BioMuta; TMEM169; -.
DR DMDM; 74731931; -.
DR MassIVE; Q96HH4; -.
DR PaxDb; Q96HH4; -.
DR PeptideAtlas; Q96HH4; -.
DR PRIDE; Q96HH4; -.
DR ProteomicsDB; 76746; -.
DR Antibodypedia; 68249; 46 antibodies from 9 providers.
DR DNASU; 92691; -.
DR Ensembl; ENST00000295658.8; ENSP00000295658.4; ENSG00000163449.11.
DR Ensembl; ENST00000406027.2; ENSP00000384100.2; ENSG00000163449.11.
DR Ensembl; ENST00000437356.7; ENSP00000401305.2; ENSG00000163449.11.
DR Ensembl; ENST00000454545.5; ENSP00000412524.1; ENSG00000163449.11.
DR GeneID; 92691; -.
DR KEGG; hsa:92691; -.
DR MANE-Select; ENST00000437356.7; ENSP00000401305.2; NM_001142311.2; NP_001135783.1.
DR UCSC; uc002vfv.5; human.
DR CTD; 92691; -.
DR GeneCards; TMEM169; -.
DR HGNC; HGNC:25130; TMEM169.
DR HPA; ENSG00000163449; Tissue enhanced (brain, retina).
DR neXtProt; NX_Q96HH4; -.
DR OpenTargets; ENSG00000163449; -.
DR PharmGKB; PA162405911; -.
DR VEuPathDB; HostDB:ENSG00000163449; -.
DR eggNOG; ENOG502QUD9; Eukaryota.
DR GeneTree; ENSGT00390000015276; -.
DR HOGENOM; CLU_082140_0_0_1; -.
DR InParanoid; Q96HH4; -.
DR OMA; AFSEWWQ; -.
DR OrthoDB; 1505889at2759; -.
DR PhylomeDB; Q96HH4; -.
DR TreeFam; TF323682; -.
DR PathwayCommons; Q96HH4; -.
DR BioGRID-ORCS; 92691; 8 hits in 1069 CRISPR screens.
DR GenomeRNAi; 92691; -.
DR Pharos; Q96HH4; Tdark.
DR PRO; PR:Q96HH4; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q96HH4; protein.
DR Bgee; ENSG00000163449; Expressed in cortical plate and 103 other tissues.
DR ExpressionAtlas; Q96HH4; baseline and differential.
DR Genevisible; Q96HH4; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR029386; TMEM169.
DR PANTHER; PTHR31777; PTHR31777; 1.
DR Pfam; PF15052; TMEM169; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..297
FT /note="Transmembrane protein 169"
FT /id="PRO_0000271039"
FT TOPO_DOM 1..159
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 181..210
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 232..297
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 1..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..63
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..85
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 297 AA; 33611 MW; 9562EF36341F16AD CRC64;
MEEPTAVEGQ VQLPSPHQGS LRKAVAAALA LDGESTMGHR KKKRKESRPE SIIIYRSDNE
KTDEEPGESE GGDQPKEEEG DDFLDYPVDD DMWNLPLDSR YVTLTGTITR GKKKGQMVDI
HVTLTEKELQ ELTKPKESSR ETTPEGRMAC QMGADRGPHV VLWTLICLPV VFILSFVVSF
YYGTITWYNI FLVYNEERTF WHKISYCPCL VLFYPVLIMA MASSLGLYAA VVQLSWSWEA
WWQAARDMEK GFCGWLCSKL GLEDCSPYSI VELLESDNIS STLSNKDPIQ EVETSTV
