TM169_MOUSE
ID TM169_MOUSE Reviewed; 297 AA.
AC Q8BG50;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Transmembrane protein 169;
GN Name=Tmem169;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain cortex, and Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK034935; BAC28886.1; -; mRNA.
DR EMBL; AK043681; BAC31618.1; -; mRNA.
DR EMBL; BC116730; AAI16731.1; -; mRNA.
DR EMBL; BC117087; AAI17088.1; -; mRNA.
DR CCDS; CCDS15033.1; -.
DR RefSeq; NP_780773.1; NM_175564.4.
DR RefSeq; XP_006496114.1; XM_006496051.1.
DR RefSeq; XP_006496115.1; XM_006496052.2.
DR RefSeq; XP_006496116.1; XM_006496053.2.
DR AlphaFoldDB; Q8BG50; -.
DR STRING; 10090.ENSMUSP00000027380; -.
DR iPTMnet; Q8BG50; -.
DR PhosphoSitePlus; Q8BG50; -.
DR MaxQB; Q8BG50; -.
DR PaxDb; Q8BG50; -.
DR PRIDE; Q8BG50; -.
DR ProteomicsDB; 260682; -.
DR Antibodypedia; 68249; 46 antibodies from 9 providers.
DR DNASU; 271711; -.
DR Ensembl; ENSMUST00000027380; ENSMUSP00000027380; ENSMUSG00000026188.
DR GeneID; 271711; -.
DR KEGG; mmu:271711; -.
DR UCSC; uc007bkk.1; mouse.
DR CTD; 92691; -.
DR MGI; MGI:2442781; Tmem169.
DR VEuPathDB; HostDB:ENSMUSG00000026188; -.
DR eggNOG; ENOG502QUD9; Eukaryota.
DR GeneTree; ENSGT00390000015276; -.
DR HOGENOM; CLU_082140_0_0_1; -.
DR InParanoid; Q8BG50; -.
DR OMA; AFSEWWQ; -.
DR OrthoDB; 1505889at2759; -.
DR PhylomeDB; Q8BG50; -.
DR TreeFam; TF323682; -.
DR BioGRID-ORCS; 271711; 3 hits in 75 CRISPR screens.
DR PRO; PR:Q8BG50; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q8BG50; protein.
DR Bgee; ENSMUSG00000026188; Expressed in secondary oocyte and 116 other tissues.
DR ExpressionAtlas; Q8BG50; baseline and differential.
DR Genevisible; Q8BG50; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR029386; TMEM169.
DR PANTHER; PTHR31777; PTHR31777; 1.
DR Pfam; PF15052; TMEM169; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..297
FT /note="Transmembrane protein 169"
FT /id="PRO_0000271040"
FT TOPO_DOM 1..159
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 181..210
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 232..297
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 1..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..62
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 297 AA; 33424 MW; C758198DB0AB34A7 CRC64;
MEESAPVESQ GQLPSPHHGS LRRAVAAVLA LDGESTLGRR KKRRKDSRPE SIIIYRSDNE
KTDEEPEESE GGDRPKEEEG EDFLDYPGDD GVWNMPLDSR YVTLTGTITR GKKKGQMVDI
HVTLTEKELQ ELTKPKELSR EAAPEGRRAC QVGADQGPHV VLWTLVCLPV VFVLSFVVSF
YYGTITWYNI FLVYNEERTF WHKISCCPCL ILFYPVLIMT MASSLGLYAA VAQLSWSWAA
WWRAACDMEK GFCGWLCSKL GLEDCSPYSI VELLESDNIS GNLSNKDPIQ EVETSTV
