TM16A_ARATH
ID TM16A_ARATH Reviewed; 113 AA.
AC Q93W66; Q9FLS3;
DT 02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Mitochondrial import inner membrane translocase subunit PAM16 like 1 {ECO:0000303|PubMed:24194927};
DE Short=AtPAM16L {ECO:0000303|PubMed:24153405};
DE Short=AtPAM16L1 {ECO:0000303|PubMed:24194927};
DE AltName: Full=Presequence translocated-associated motor subunit PAM16L {ECO:0000250|UniProtKB:P42949};
DE AltName: Full=Protein MUTANT SNC1-ENHANCING 5 LIKE {ECO:0000303|PubMed:24153405};
DE Flags: Precursor;
GN Name=PAM16L1 {ECO:0000303|PubMed:24194927};
GN Synonyms=MUSE5L {ECO:0000303|PubMed:24153405},
GN PAM16L {ECO:0000303|PubMed:24153405};
GN OrderedLocusNames=At5g61880 {ECO:0000312|Araport:AT5G61880};
GN ORFNames=MAC9.20 {ECO:0000312|EMBL:BAB10087.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9628582; DOI=10.1093/dnares/5.1.41;
RA Sato S., Kaneko T., Kotani H., Nakamura Y., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. IV. Sequence
RT features of the regions of 1,456,315 bp covered by nineteen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:41-54(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP DISRUPTION PHENOTYPE.
RC STRAIN=cv. Columbia;
RX PubMed=24153405; DOI=10.1038/ncomms3558;
RA Huang Y., Chen X., Liu Y., Roth C., Copeland C., McFarlane H.E., Huang S.,
RA Lipka V., Wiermer M., Li X.;
RT "Mitochondrial AtPAM16 is required for plant survival and the negative
RT regulation of plant immunity.";
RL Nat. Commun. 4:2558-2558(2013).
RN [6]
RP DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, INDUCTION BY HEAT AND SALT, GENE
RP FAMILY, NOMENCLATURE, AND REVIEW.
RX PubMed=24194927; DOI=10.1371/journal.pone.0078400;
RA Chen X., Ghazanfar B., Khan A.R., Hayat S., Cheng Z.;
RT "Comparative analysis of putative orthologues of mitochondrial import motor
RT subunit: Pam18 and Pam16 in plants.";
RL PLoS ONE 8:E78400-E78400(2013).
CC -!- FUNCTION: Regulates ATP-dependent protein translocation into the
CC mitochondrial matrix. {ECO:0000250|UniProtKB:Q9Y3D7}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q93VV9}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:Q93VV9}.
CC -!- TISSUE SPECIFICITY: Expressed at low levels in seedlings, rosettes and
CC inflorescence. {ECO:0000269|PubMed:24194927}.
CC -!- DEVELOPMENTAL STAGE: Accumulates during senescence.
CC {ECO:0000269|PubMed:24194927}.
CC -!- INDUCTION: Induced by heat and salt stresses.
CC {ECO:0000269|PubMed:24194927}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype and normal sensitivity to
CC pathogens, but higher expression of pathogenesis related genes PR-1 and
CC PR-2 in Atpam16l. The double mutant Atpam16-1 Atpam16l is lethal.
CC {ECO:0000269|PubMed:24153405}.
CC -!- SIMILARITY: Belongs to the TIM16/PAM16 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB10087.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB010069; BAB10087.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED97527.1; -; Genomic_DNA.
DR EMBL; CP002688; AED97528.1; -; Genomic_DNA.
DR EMBL; AY039584; AAK62639.1; -; mRNA.
DR EMBL; AY054150; AAL06811.1; -; mRNA.
DR EMBL; AY085331; AAM62562.1; -; mRNA.
DR RefSeq; NP_001331745.1; NM_001345501.1.
DR RefSeq; NP_568943.1; NM_125581.2.
DR RefSeq; NP_851243.1; NM_180912.3.
DR AlphaFoldDB; Q93W66; -.
DR SMR; Q93W66; -.
DR STRING; 3702.AT5G61880.1; -.
DR PaxDb; Q93W66; -.
DR PRIDE; Q93W66; -.
DR ProteomicsDB; 234283; -.
DR EnsemblPlants; AT5G61880.1; AT5G61880.1; AT5G61880.
DR EnsemblPlants; AT5G61880.2; AT5G61880.2; AT5G61880.
DR GeneID; 836309; -.
DR Gramene; AT5G61880.1; AT5G61880.1; AT5G61880.
DR Gramene; AT5G61880.2; AT5G61880.2; AT5G61880.
DR KEGG; ath:AT5G61880; -.
DR Araport; AT5G61880; -.
DR TAIR; locus:2159228; AT5G61880.
DR eggNOG; KOG3442; Eukaryota.
DR HOGENOM; CLU_101461_2_0_1; -.
DR InParanoid; Q93W66; -.
DR OMA; QKMFEAN; -.
DR OrthoDB; 1640138at2759; -.
DR PhylomeDB; Q93W66; -.
DR PRO; PR:Q93W66; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q93W66; baseline and differential.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005744; C:TIM23 mitochondrial import inner membrane translocase complex; IBA:GO_Central.
DR GO; GO:0031348; P:negative regulation of defense response; IMP:TAIR.
DR GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR Gene3D; 1.10.287.110; -; 1.
DR InterPro; IPR036869; J_dom_sf.
DR InterPro; IPR005341; Tim16.
DR PANTHER; PTHR12388; PTHR12388; 1.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Protein transport;
KW Reference proteome; Transit peptide; Translocation; Transport.
FT TRANSIT 1..48
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 49..113
FT /note="Mitochondrial import inner membrane translocase
FT subunit PAM16 like 1"
FT /id="PRO_0000437996"
FT REGION 55..104
FT /note="J-like"
FT /evidence="ECO:0000250|UniProtKB:P42949"
SQ SEQUENCE 113 AA; 12311 MW; 4DB15D6C29425D9B CRC64;
MAARVLASVI VMGSGIIARA CTQAYRQALA NASKTGVAHE ATQTIKRGLT IGEAEARQIL
GVTEKSSWDE ILKKYDTLFE RNAQNGSFYL QSKVHRAKEC LETAYQKSTT TSA
