TM171_HUMAN
ID TM171_HUMAN Reviewed; 324 AA.
AC Q8WVE6; Q8N0S1; Q8TDT7;
DT 19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 19-SEP-2006, sequence version 3.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Transmembrane protein 171;
GN Name=TMEM171;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS GLY-86 AND LYS-139.
RX PubMed=12044878; DOI=10.1016/s0014-5793(02)02775-8;
RA Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.;
RT "Identification of G protein-coupled receptor genes from the human genome
RT sequence.";
RL FEBS Lett. 520:97-101(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP LEU-23.
RC TISSUE=Brain, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8WVE6; Q8N108-14: MIER1; NbExp=3; IntAct=EBI-10264837, EBI-10264833;
CC Q8WVE6-2; P13473-2: LAMP2; NbExp=3; IntAct=EBI-25874374, EBI-21591415;
CC Q8WVE6-2; O75400-2: PRPF40A; NbExp=3; IntAct=EBI-25874374, EBI-5280197;
CC Q8WVE6-2; Q9Y371: SH3GLB1; NbExp=3; IntAct=EBI-25874374, EBI-2623095;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8WVE6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8WVE6-2; Sequence=VSP_020520;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB89327.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB083614; BAB89327.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC018083; AAH18083.2; -; mRNA.
DR EMBL; BC035310; AAH35310.1; -; mRNA.
DR CCDS; CCDS4017.1; -. [Q8WVE6-1]
DR CCDS; CCDS54869.1; -. [Q8WVE6-2]
DR RefSeq; NP_001154814.1; NM_001161342.2. [Q8WVE6-2]
DR RefSeq; NP_775761.4; NM_173490.7. [Q8WVE6-1]
DR AlphaFoldDB; Q8WVE6; -.
DR BioGRID; 126392; 79.
DR IntAct; Q8WVE6; 49.
DR STRING; 9606.ENSP00000415030; -.
DR iPTMnet; Q8WVE6; -.
DR PhosphoSitePlus; Q8WVE6; -.
DR BioMuta; TMEM171; -.
DR DMDM; 115311873; -.
DR MassIVE; Q8WVE6; -.
DR PaxDb; Q8WVE6; -.
DR PeptideAtlas; Q8WVE6; -.
DR PRIDE; Q8WVE6; -.
DR ProteomicsDB; 74782; -. [Q8WVE6-1]
DR ProteomicsDB; 74783; -. [Q8WVE6-2]
DR Antibodypedia; 24256; 18 antibodies from 11 providers.
DR DNASU; 134285; -.
DR Ensembl; ENST00000287773.5; ENSP00000287773.5; ENSG00000157111.13. [Q8WVE6-2]
DR Ensembl; ENST00000454765.7; ENSP00000415030.2; ENSG00000157111.13. [Q8WVE6-1]
DR GeneID; 134285; -.
DR KEGG; hsa:134285; -.
DR MANE-Select; ENST00000454765.7; ENSP00000415030.2; NM_173490.8; NP_775761.4.
DR UCSC; uc003kcm.3; human. [Q8WVE6-1]
DR CTD; 134285; -.
DR DisGeNET; 134285; -.
DR GeneCards; TMEM171; -.
DR HGNC; HGNC:27031; TMEM171.
DR HPA; ENSG00000157111; Group enriched (intestine, kidney, lymphoid tissue, stomach, thyroid gland).
DR neXtProt; NX_Q8WVE6; -.
DR OpenTargets; ENSG00000157111; -.
DR PharmGKB; PA162405933; -.
DR VEuPathDB; HostDB:ENSG00000157111; -.
DR eggNOG; ENOG502QRR0; Eukaryota.
DR GeneTree; ENSGT00390000017024; -.
DR HOGENOM; CLU_900031_0_0_1; -.
DR InParanoid; Q8WVE6; -.
DR OMA; QNEQVYS; -.
DR OrthoDB; 1046807at2759; -.
DR PhylomeDB; Q8WVE6; -.
DR TreeFam; TF335590; -.
DR PathwayCommons; Q8WVE6; -.
DR SignaLink; Q8WVE6; -.
DR BioGRID-ORCS; 134285; 12 hits in 1066 CRISPR screens.
DR GenomeRNAi; 134285; -.
DR Pharos; Q8WVE6; Tdark.
DR PRO; PR:Q8WVE6; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q8WVE6; protein.
DR Bgee; ENSG00000157111; Expressed in mucosa of transverse colon and 107 other tissues.
DR Genevisible; Q8WVE6; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR029173; TMEM171.
DR PANTHER; PTHR31617; PTHR31617; 1.
DR Pfam; PF15471; TMEM171; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..324
FT /note="Transmembrane protein 171"
FT /id="PRO_0000249570"
FT TRANSMEM 22..42
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 229..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 279..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 279..294
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 262
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_020520"
FT VARIANT 23
FT /note="F -> L (in dbSNP:rs638333)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_057003"
FT VARIANT 86
FT /note="R -> G (in dbSNP:rs637450)"
FT /evidence="ECO:0000269|PubMed:12044878"
FT /id="VAR_057004"
FT VARIANT 139
FT /note="N -> K (in dbSNP:rs636926)"
FT /evidence="ECO:0000269|PubMed:12044878"
FT /id="VAR_057005"
FT CONFLICT 323
FT /note="P -> S (in Ref. 2; AAH35310)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 324 AA; 34760 MW; 0EDE5EA8F05C7AE1 CRC64;
MSPAAAAEPD GDQQDRHVSK LIFCFFVFGA VLLCVGVLLS IFGFQACQYK PLPDCPMVLK
VAGPACAVVG LGAVILARSR AQLQLRAGLQ RGQQMDPDRA FICGESRQFA QCLIFGFLFL
TSGMLISVLG IWVPGCGSNW AQEPLNETDT GDSEPRMCGF LSLQIMGPLI VLVGLCFFVV
AHVKKRNTLN AGQDASEREE GQIQIMEPVQ VTVGDSVIIF PPPPPPYFPE SSASAVAESP
GTNSLLPNEN PPSYYSIFNY GRTPTSEGAA SERDCESIYT ISGTNSSSEA SHTPHLPSEL
PPRYEEKENA AATFLPLSSE PSPP
