TM174_HUMAN
ID TM174_HUMAN Reviewed; 243 AA.
AC Q8WUU8; B2RDA0; Q96N81;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Transmembrane protein 174;
GN Name=TMEM174;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Kidney;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=20331980; DOI=10.1016/j.bbrc.2010.03.109;
RA Wang P., Sun B., Hao D., Zhang X., Shi T., Ma D.;
RT "Human TMEM174 that is highly expressed in kidney tissue activates AP-1 and
RT promotes cell proliferation.";
RL Biochem. Biophys. Res. Commun. 394:993-999(2010).
CC -!- INTERACTION:
CC Q8WUU8; O95817: BAG3; NbExp=3; IntAct=EBI-10276729, EBI-747185;
CC Q8WUU8; Q08289: CACNB2; NbExp=3; IntAct=EBI-10276729, EBI-2874501;
CC Q8WUU8; Q96FZ5: CMTM7; NbExp=4; IntAct=EBI-10276729, EBI-2807956;
CC Q8WUU8; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-10276729, EBI-3867333;
CC Q8WUU8; P50402: EMD; NbExp=3; IntAct=EBI-10276729, EBI-489887;
CC Q8WUU8; O14901: KLF11; NbExp=3; IntAct=EBI-10276729, EBI-948266;
CC Q8WUU8; Q15323: KRT31; NbExp=3; IntAct=EBI-10276729, EBI-948001;
CC Q8WUU8; O76011: KRT34; NbExp=3; IntAct=EBI-10276729, EBI-1047093;
CC Q8WUU8; P21145: MAL; NbExp=3; IntAct=EBI-10276729, EBI-3932027;
CC Q8WUU8; Q9Y342: PLLP; NbExp=3; IntAct=EBI-10276729, EBI-3919291;
CC Q8WUU8; Q96IW7: SEC22A; NbExp=3; IntAct=EBI-10276729, EBI-8652744;
CC Q8WUU8; O43765: SGTA; NbExp=6; IntAct=EBI-10276729, EBI-347996;
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:20331980}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:20331980}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8WUU8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8WUU8-2; Sequence=VSP_024210;
CC -!- TISSUE SPECIFICITY: Predominantly expressed in kidney.
CC {ECO:0000269|PubMed:20331980}.
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DR EMBL; AK055830; BAB71025.1; -; mRNA.
DR EMBL; AK315460; BAG37847.1; -; mRNA.
DR EMBL; CH471084; EAW95719.1; -; Genomic_DNA.
DR EMBL; BC019346; AAH19346.1; -; mRNA.
DR CCDS; CCDS4018.1; -. [Q8WUU8-1]
DR RefSeq; NP_694949.1; NM_153217.2. [Q8WUU8-1]
DR AlphaFoldDB; Q8WUU8; -.
DR BioGRID; 126393; 33.
DR IntAct; Q8WUU8; 13.
DR STRING; 9606.ENSP00000296776; -.
DR PhosphoSitePlus; Q8WUU8; -.
DR BioMuta; TMEM174; -.
DR DMDM; 74730764; -.
DR MassIVE; Q8WUU8; -.
DR PaxDb; Q8WUU8; -.
DR PRIDE; Q8WUU8; -.
DR Antibodypedia; 48787; 52 antibodies from 15 providers.
DR DNASU; 134288; -.
DR Ensembl; ENST00000296776.6; ENSP00000296776.5; ENSG00000164325.8. [Q8WUU8-1]
DR GeneID; 134288; -.
DR KEGG; hsa:134288; -.
DR MANE-Select; ENST00000296776.6; ENSP00000296776.5; NM_153217.3; NP_694949.1.
DR UCSC; uc010izc.4; human. [Q8WUU8-1]
DR CTD; 134288; -.
DR GeneCards; TMEM174; -.
DR HGNC; HGNC:28187; TMEM174.
DR HPA; ENSG00000164325; Tissue enriched (kidney).
DR MIM; 614909; gene.
DR neXtProt; NX_Q8WUU8; -.
DR OpenTargets; ENSG00000164325; -.
DR PharmGKB; PA162405935; -.
DR VEuPathDB; HostDB:ENSG00000164325; -.
DR eggNOG; ENOG502RZ98; Eukaryota.
DR GeneTree; ENSGT00390000004161; -.
DR HOGENOM; CLU_099888_0_0_1; -.
DR InParanoid; Q8WUU8; -.
DR OMA; YYTIYPP; -.
DR PhylomeDB; Q8WUU8; -.
DR TreeFam; TF335512; -.
DR PathwayCommons; Q8WUU8; -.
DR SignaLink; Q8WUU8; -.
DR BioGRID-ORCS; 134288; 9 hits in 1056 CRISPR screens.
DR GenomeRNAi; 134288; -.
DR Pharos; Q8WUU8; Tdark.
DR PRO; PR:Q8WUU8; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q8WUU8; protein.
DR Bgee; ENSG00000164325; Expressed in kidney epithelium and 43 other tissues.
DR ExpressionAtlas; Q8WUU8; baseline and differential.
DR Genevisible; Q8WUU8; HS.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR027835; TMEM174.
DR PANTHER; PTHR31020; PTHR31020; 1.
DR Pfam; PF15029; TMEM174; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Endoplasmic reticulum; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..243
FT /note="Transmembrane protein 174"
FT /id="PRO_0000282577"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 210..243
FT /note="PNPDVDQLEETQLEEEACACFSPPPYEEIYSLPR -> YGPILMLTS (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_024210"
SQ SEQUENCE 243 AA; 26287 MW; 05A764F265B50258 CRC64;
MEQGSGRLED FPVNVFSVTP YTPSTADIQV SDDDKAGATL LFSGIFLGLV GITFTVMGWI
KYQGVSHFEW TQLLGPVLLS VGVTFILIAV CKFKMLSCQL CKESEERVPD SEQTPGGPSF
VFTGINQPIT FHGATVVQYI PPPYGSPEPM GINTSYLQSV VSPCGLITSG GAAAAMSSPP
QYYTIYPQDN SAFVVDEGCL SFTDGGNHRP NPDVDQLEET QLEEEACACF SPPPYEEIYS
LPR
