TM174_MOUSE
ID TM174_MOUSE Reviewed; 243 AA.
AC Q9DCX7; Q96LY0;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Transmembrane protein 174;
GN Name=Tmem174;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Suzuki O., Sasaki N., Aotsuka S., Shoji T., Ichihara T., Shiohata N.,
RA Matsumoto K., Hirano M., Sano S., Nomura R., Yoshikawa Y., Matsumura Y.,
RA Moriya S., Chiba E., Momiyama H., Onogawa S., Kaeriyama S., Satoh N.,
RA Matsunawa H., Takahashi E., Kataoka R., Kuga N., Kuroda A., Satoh I.,
RA Kamata K., Takami S., Terashima Y., Watanabe M., Sugiyama T., Irie R.,
RA Otsuki T., Sato H., Ota T., Wakamatsu A., Ishii S., Yamamoto J., Isono Y.,
RA Kawai-Hio Y., Saito K., Nishikawa T., Kimura K., Yamashita H., Matsuo K.,
RA Nakamura Y., Sekine M., Kikuchi H., Kanda K., Wagatsuma M., Murakawa K.,
RA Kanehori K., Takahashi-Fujii A., Oshima A., Sugiyama A., Kawakami B.,
RA Suzuki Y., Sugano S., Nagahari K., Masuho Y., Nagai K., Isogai T.;
RT "NEDO cDNA sequencing project.";
RL Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
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DR EMBL; AK002365; BAB22043.1; -; mRNA.
DR EMBL; AK057630; BAB71536.1; -; mRNA.
DR EMBL; BC030878; AAH30878.1; -; mRNA.
DR CCDS; CCDS26715.1; -.
DR RefSeq; NP_080961.1; NM_026685.2.
DR AlphaFoldDB; Q9DCX7; -.
DR STRING; 10090.ENSMUSP00000057581; -.
DR iPTMnet; Q9DCX7; -.
DR PhosphoSitePlus; Q9DCX7; -.
DR PaxDb; Q9DCX7; -.
DR PRIDE; Q9DCX7; -.
DR ProteomicsDB; 259465; -.
DR Antibodypedia; 48787; 52 antibodies from 15 providers.
DR DNASU; 68344; -.
DR Ensembl; ENSMUST00000050389; ENSMUSP00000057581; ENSMUSG00000046082.
DR GeneID; 68344; -.
DR KEGG; mmu:68344; -.
DR UCSC; uc011zdk.1; mouse.
DR CTD; 134288; -.
DR MGI; MGI:1915594; Tmem174.
DR VEuPathDB; HostDB:ENSMUSG00000046082; -.
DR eggNOG; ENOG502RZ98; Eukaryota.
DR GeneTree; ENSGT00390000004161; -.
DR HOGENOM; CLU_099888_0_0_1; -.
DR InParanoid; Q9DCX7; -.
DR OMA; YYTIYPP; -.
DR OrthoDB; 1122990at2759; -.
DR PhylomeDB; Q9DCX7; -.
DR TreeFam; TF335512; -.
DR BioGRID-ORCS; 68344; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q9DCX7; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q9DCX7; protein.
DR Bgee; ENSMUSG00000046082; Expressed in adult mammalian kidney and 22 other tissues.
DR Genevisible; Q9DCX7; MM.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR027835; TMEM174.
DR PANTHER; PTHR31020; PTHR31020; 1.
DR Pfam; PF15029; TMEM174; 1.
PE 1: Evidence at protein level;
KW Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..243
FT /note="Transmembrane protein 174"
FT /id="PRO_0000282578"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 79
FT /note="L -> P (in Ref. 2; BAB71536)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 243 AA; 26449 MW; 98D1193C1C96111D CRC64;
MEHSSNRPED FPLNVFSVTP YTPSTADIQV SDDDKAGATL LFSGIFLGLV GITFTVMGWI
KYQGVSHFEW TQLLGPILLS VGVTFILIAV CKFKMLSCQL CSDNEERVPD SDQTSGGQSF
VFTGINQPIT FHGATVVQYI PPPYGSQEPL GMNATYLQPM MNPCGLIPPS GAAAAAPSPP
QYYTIYPQDN AAFVESEGFS PFVGTGYDRP DSDADQLEGT ELEEEDCVCF SPPPYEEIYA
LPR
