ID   TM174_RAT               Reviewed;         243 AA.
AC   Q68FU0;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Transmembrane protein 174;
GN   Name=Tmem174;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
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DR   EMBL; BC079357; AAH79357.1; -; mRNA.
DR   RefSeq; NP_001019469.1; NM_001024298.1.
DR   AlphaFoldDB; Q68FU0; -.
DR   STRING; 10116.ENSRNOP00000020879; -.
DR   PaxDb; Q68FU0; -.
DR   Ensembl; ENSRNOT00000020879; ENSRNOP00000020879; ENSRNOG00000015472.
DR   GeneID; 499516; -.
DR   KEGG; rno:499516; -.
DR   UCSC; RGD:1561129; rat.
DR   CTD; 134288; -.
DR   RGD; 1561129; Tmem174.
DR   eggNOG; ENOG502RZ98; Eukaryota.
DR   GeneTree; ENSGT00390000004161; -.
DR   HOGENOM; CLU_099888_0_0_1; -.
DR   InParanoid; Q68FU0; -.
DR   OMA; YYTIYPP; -.
DR   OrthoDB; 1122990at2759; -.
DR   PhylomeDB; Q68FU0; -.
DR   TreeFam; TF335512; -.
DR   PRO; PR:Q68FU0; -.
DR   Proteomes; UP000002494; Chromosome 2.
DR   Bgee; ENSRNOG00000015472; Expressed in adult mammalian kidney and 3 other tissues.
DR   Genevisible; Q68FU0; RN.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR027835; TMEM174.
DR   PANTHER; PTHR31020; PTHR31020; 1.
DR   Pfam; PF15029; TMEM174; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..243
FT                   /note="Transmembrane protein 174"
FT                   /id="PRO_0000282580"
FT   TRANSMEM        40..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          205..229
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   243 AA;  26478 MW;  7892FF53CE7EDD57 CRC64;
     MEQSSNRPED FPLNVFSVTP YTPSTADIQV SDDDKAGATL LFSGIFLGLV GITFTVMGWI
     KYQGVSHFEW TQLLGPILLS VGVTFILISV CKFKMLSCQL CTDNEERVLD SDQTSGGQSF
     VFTGINQPIT FHGATVVQYI PPPYGSQEPL GMNTTYLQPM MNPCGLVPSS GAVAATPSPP
     QYYTIYPQDN AAFVESEGFS PFVGAGHDRP SSDADQLEGT QMGEEERVCF SPPPYEEIYA
     LPR