ID   TM177_DANRE             Reviewed;         310 AA.
AC   Q6PBI8;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Transmembrane protein 177;
GN   Name=tmem177; ORFNames=zgc:73384;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in the early steps of cytochrome c oxidase
CC       subunit II (MT-CO2/COX2) maturation and is required for the
CC       stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein.
CC       {ECO:0000250|UniProtKB:Q53S58}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q53S58}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TMEM177 family. {ECO:0000305}.
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DR   EMBL; BC059692; AAH59692.1; -; mRNA.
DR   RefSeq; NP_955888.1; NM_199594.1.
DR   AlphaFoldDB; Q6PBI8; -.
DR   STRING; 7955.ENSDARP00000091517; -.
DR   PaxDb; Q6PBI8; -.
DR   Ensembl; ENSDART00000100744; ENSDARP00000091517; ENSDARG00000069301.
DR   Ensembl; ENSDART00000160393; ENSDARP00000134056; ENSDARG00000069301.
DR   GeneID; 556875; -.
DR   KEGG; dre:556875; -.
DR   CTD; 80775; -.
DR   ZFIN; ZDB-GENE-030131-993; tmem177.
DR   eggNOG; ENOG502QPPU; Eukaryota.
DR   GeneTree; ENSGT00390000010354; -.
DR   HOGENOM; CLU_074208_0_0_1; -.
DR   InParanoid; Q6PBI8; -.
DR   OMA; HTFGLKY; -.
DR   OrthoDB; 1039066at2759; -.
DR   PhylomeDB; Q6PBI8; -.
DR   TreeFam; TF328369; -.
DR   PRO; PR:Q6PBI8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 9.
DR   Bgee; ENSDARG00000069301; Expressed in muscle tissue and 27 other tissues.
DR   ExpressionAtlas; Q6PBI8; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; ISS:UniProtKB.
DR   InterPro; IPR026620; TMEM177.
DR   PANTHER; PTHR21824; PTHR21824; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..310
FT                   /note="Transmembrane protein 177"
FT                   /id="PRO_0000282649"
FT   TOPO_DOM        1..17
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        18..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        39..169
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        170..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        191..200
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        201..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        222..310
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   310 AA;  34029 MW;  CE6BAF214F487DB6 CRC64;
     MSSRFLKISV FIQKYRTPLL LIGCGGVFSA NIFYHIFPDH TYKKVYQAWH KGEPASLSEK
     LQNIFQEVLK DSSISTSGNF SAFAAFGFHP VGAGVPWLPS GAQIGIPANF NSSTADLEGI
     TNRTILINGK ELEWDSDSGV ALKNSLVFSL EAQKFAIARE VARLGSGGPI LHAAVAPVCL
     AGACVYSVAL KQIFRFQAGS IIFRGVVNLL SLGLGVMTYV LAADSVSQWL DYRSDRRAAG
     LSRDYAKGGL EFYEKILTRN KTLRSLMGQK GEEMYAPSGN LFPAHLLQLR HATYTSRRDR
     ILNLLKNENV