ID   TM177_RAT               Reviewed;         311 AA.
AC   Q4KM93;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Transmembrane protein 177;
GN   Name=Tmem177;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Thymus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Plays a role in the early steps of cytochrome c oxidase
CC       subunit II (MT-CO2/COX2) maturation and is required for the
CC       stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein.
CC       {ECO:0000250|UniProtKB:Q53S58}.
CC   -!- SUBUNIT: Found in a complex with COX20, COA6, MT-CO2/COX2, COX18, SCO1
CC       and SCO2. Interacts with COX20. Interacts with COX1, MT-CO2/COX2, SCO1
CC       and SCO2 in a COX20-dependent manner. {ECO:0000250|UniProtKB:Q53S58}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q53S58}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TMEM177 family. {ECO:0000305}.
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DR   EMBL; BC098688; AAH98688.1; -; mRNA.
DR   RefSeq; NP_001032865.1; NM_001037776.1.
DR   RefSeq; XP_006249726.1; XM_006249664.3.
DR   RefSeq; XP_006249727.1; XM_006249665.3.
DR   AlphaFoldDB; Q4KM93; -.
DR   STRING; 10116.ENSRNOP00000036312; -.
DR   PaxDb; Q4KM93; -.
DR   PRIDE; Q4KM93; -.
DR   Ensembl; ENSRNOT00000039074; ENSRNOP00000036312; ENSRNOG00000025484.
DR   Ensembl; ENSRNOT00000102460; ENSRNOP00000094878; ENSRNOG00000025484.
DR   Ensembl; ENSRNOT00000118103; ENSRNOP00000087342; ENSRNOG00000025484.
DR   GeneID; 304735; -.
DR   KEGG; rno:304735; -.
DR   CTD; 80775; -.
DR   RGD; 1310320; Tmem177.
DR   eggNOG; ENOG502QPPU; Eukaryota.
DR   GeneTree; ENSGT00390000010354; -.
DR   HOGENOM; CLU_074208_0_0_1; -.
DR   InParanoid; Q4KM93; -.
DR   OMA; HTFGLKY; -.
DR   OrthoDB; 1039066at2759; -.
DR   PhylomeDB; Q4KM93; -.
DR   TreeFam; TF328369; -.
DR   PRO; PR:Q4KM93; -.
DR   Proteomes; UP000002494; Chromosome 13.
DR   Bgee; ENSRNOG00000025484; Expressed in skeletal muscle tissue and 19 other tissues.
DR   Genevisible; Q4KM93; RN.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; ISS:UniProtKB.
DR   InterPro; IPR026620; TMEM177.
DR   PANTHER; PTHR21824; PTHR21824; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..311
FT                   /note="Transmembrane protein 177"
FT                   /id="PRO_0000282648"
FT   TOPO_DOM        1..17
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        18..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        39..164
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        186..197
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        198..218
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        219..311
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   311 AA;  34001 MW;  B89E69AABF20273F CRC64;
     MAGPLWRAAV FIQRHRTSLL VGSCVGLFGV QISFHLFPDP IVQWLYQYWP QGQPAPLSPQ
     LRSLFQEVLK DIGVPSGHCY KPFTAFTFQP VSAGFPQLPA GAVVGIPAIF LGGLVTNIDH
     TVVIHGQKVD WQSPAGTRLR DALTLSHDAQ KFALAKEVVY LESGMAALQT LPAPVCLAGT
     WAISVGAKHA LGLYGGPMSL RAAFNLVAIV VGYVAYAFSK DSLTVALEGW LDHRTASLSA
     AYVRGGVEFY EKILSGNLAL RSLLGRQGEK LYTPSGNIVP RHWFRINHLP YTTRRDSLLQ
     MWRAKVSPGH F