ID   TM177_XENLA             Reviewed;         310 AA.
AC   Q66IS8;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 2.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Transmembrane protein 177;
GN   Name=tmem177;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in the early steps of cytochrome c oxidase
CC       subunit II (MT-CO2/COX2) maturation and is required for the
CC       stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein.
CC       {ECO:0000250|UniProtKB:Q53S58}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q53S58}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TMEM177 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH81215.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC081215; AAH81215.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; Q66IS8; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; ISS:UniProtKB.
DR   InterPro; IPR026620; TMEM177.
DR   PANTHER; PTHR21824; PTHR21824; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..310
FT                   /note="Transmembrane protein 177"
FT                   /id="PRO_0000282650"
FT   TOPO_DOM        1..17
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        18..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        39..170
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        171..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        192..201
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        223..310
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   310 AA;  34198 MW;  49A65D7D110537C6 CRC64;
     MSSPFLWRFL SFTQKYRGTL LAVSSVGLFA ANISYHVAPE QTFRKLYQGW SKGEPVQLTA
     KLQGLFQEVL EETHMGVTSS YVPFSAFGFH PVSAGIPWLP SGCLIGIPFN YNDTEQDGVG
     IADRVLLING KEVDWSSDAG THLRQALNLS LDAQKFSLAR EVFYAQGNSP IIQASAAPVC
     LSGICLSSVA IKQLLGLYSG PILLRGVYNM AVVVLGFAGY FLCSDAVSQW LDYQSDRKVA
     AVSKSYATGG IEFYEKILAQ NRILRTLMGK QGETMYSPSG NLFPNDYLRL KNAPYTSRRD
     RIKNALLQME