ID   TM17A_XENTR             Reviewed;         187 AA.
AC   Q5HZD4;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Transmembrane protein 17A;
GN   Name=tmem17-a;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transmembrane component of the tectonic-like complex, a
CC       complex localized at the transition zone of primary cilia and acting as
CC       a barrier that prevents diffusion of transmembrane proteins between the
CC       cilia and plasma membranes. Required for ciliogenesis and sonic
CC       hedgehog/SHH signaling (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Part of the tectonic-like complex (also named B9 complex).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}. Note=Localizes to the
CC       transition zone of primary cilia. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TMEM17 family. {ECO:0000305}.
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DR   EMBL; BC089071; AAH89071.1; -; mRNA.
DR   RefSeq; NP_001015683.1; NM_001015683.1.
DR   AlphaFoldDB; Q5HZD4; -.
DR   DNASU; 548354; -.
DR   GeneID; 548354; -.
DR   KEGG; xtr:548354; -.
DR   CTD; 548354; -.
DR   Xenbase; XB-GENE-6456878; tmem17l.
DR   InParanoid; Q5HZD4; -.
DR   OrthoDB; 1544916at2759; -.
DR   PhylomeDB; Q5HZD4; -.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0060170; C:ciliary membrane; ISS:UniProtKB.
DR   GO; GO:0035869; C:ciliary transition zone; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0036038; C:MKS complex; ISS:UniProtKB.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:1905515; P:non-motile cilium assembly; IBA:GO_Central.
DR   GO; GO:0007224; P:smoothened signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR019184; Uncharacterised_TM-17.
DR   PANTHER; PTHR13531; PTHR13531; 1.
DR   Pfam; PF09799; Transmemb_17; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cell projection; Cilium; Cilium biogenesis/degradation;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..187
FT                   /note="Transmembrane protein 17A"
FT                   /id="PRO_0000255264"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   187 AA;  21122 MW;  048A0DC6F2EC4843 CRC64;
     MAQAAGVRRQ LDSLTRNIFL RDVGRTVPEK SGAPLTGDSE VAPSVSLQIF LYFNAFYFPF
     WWVCYVIMLQ LKYVLLPDYY KFILVVLLIL MSVIEVIRLY LGYSGNLQEK VPELAGFCLL
     SILLQLPLLL FLLCDPGLEP LPLERAVHGI LTAFLLIQIP ISIFALRKAT RHLAGRFHLL
     GDLDGRA