ID   TM17B_XENTR             Reviewed;         219 AA.
AC   F6RWY9; A4II27;
DT   22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT   22-FEB-2012, sequence version 2.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=Transmembrane protein 17B;
GN   Name=Tmem17-b;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA   Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA   Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA   Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA   Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA   Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA   Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA   Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-219.
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transmembrane component of the tectonic-like complex, a
CC       complex localized at the transition zone of primary cilia and acting as
CC       a barrier that prevents diffusion of transmembrane proteins between the
CC       cilia and plasma membranes. Required for ciliogenesis and sonic
CC       hedgehog/SHH signaling (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Part of the tectonic-like complex (also named B9 complex).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}. Note=Localizes to the
CC       transition zone of primary cilia. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TMEM17 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI35818.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AAMC01003686; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC135817; AAI35818.1; ALT_INIT; mRNA.
DR   RefSeq; XP_002931754.1; XM_002931708.3.
DR   AlphaFoldDB; F6RWY9; -.
DR   STRING; 8364.ENSXETP00000062848; -.
DR   PaxDb; F6RWY9; -.
DR   Ensembl; ENSXETT00000061614; ENSXETP00000062848; ENSXETG00000032054.
DR   GeneID; 100124937; -.
DR   KEGG; xtr:100124937; -.
DR   CTD; 200728; -.
DR   Xenbase; XB-GENE-5865173; tmem17.
DR   eggNOG; KOG4694; Eukaryota.
DR   HOGENOM; CLU_092836_0_0_1; -.
DR   InParanoid; F6RWY9; -.
DR   OMA; HAEMSPI; -.
DR   OrthoDB; 1544916at2759; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000032054; Expressed in embryo.
DR   GO; GO:0060170; C:ciliary membrane; ISS:UniProtKB.
DR   GO; GO:0035869; C:ciliary transition zone; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0036038; C:MKS complex; ISS:UniProtKB.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:1905515; P:non-motile cilium assembly; IBA:GO_Central.
DR   GO; GO:0007224; P:smoothened signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR019184; Uncharacterised_TM-17.
DR   PANTHER; PTHR13531; PTHR13531; 1.
DR   Pfam; PF09799; Transmemb_17; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cell projection; Cilium; Cilium biogenesis/degradation;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..219
FT                   /note="Transmembrane protein 17B"
FT                   /id="PRO_0000415839"
FT   TRANSMEM        51..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        116..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        26
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        195
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        203
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   219 AA;  25067 MW;  4E63425ECF44ABE0 CRC64;
     MALLTPLPGS VRHGLARISG SLFIQNKTRD CGEQHAYQSG HDLLSSLPLQ MMLYFNAFFF
     PFWIISEIIT MELKFGRLSG YYQILLTTSL VILTLVESLR LYIGYVGNLH EKVPELAGFL
     ILTLLIQLPL LLFLLTDNRN LLLPLDLAVH MIYLMFINAE IVISFLVLKT MTRQFALEYY
     LQQSEILVSK HVPVNRTLLR FQNTTTSIAE QYGSDALMY