ID   TM182_BOVIN             Reviewed;         229 AA.
AC   A4IF75;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Transmembrane protein 182;
DE   Flags: Precursor;
GN   Name=TMEM182;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Heart ventricle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negatively regulates myogenesis and skeletal muscle
CC       regeneration via its association with ITGB1 (By similarity). Modulates
CC       ITGB1 activation by decreasing ITGB1-LAMB1 interaction and inhibiting
CC       ITGB1-mediated intracellular signaling during myogenesis (By
CC       similarity). {ECO:0000250|UniProtKB:A0A1D5NY17}.
CC   -!- SUBUNIT: Interacts with ITGB1. {ECO:0000250|UniProtKB:A0A1D5NY17}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:A0A1D5NY17};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TMEM182 family. {ECO:0000305}.
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DR   EMBL; BC134437; AAI34438.1; -; mRNA.
DR   RefSeq; NP_001077253.1; NM_001083784.1.
DR   AlphaFoldDB; A4IF75; -.
DR   STRING; 9913.ENSBTAP00000049465; -.
DR   PaxDb; A4IF75; -.
DR   PRIDE; A4IF75; -.
DR   Ensembl; ENSBTAT00000052061; ENSBTAP00000049465; ENSBTAG00000038462.
DR   GeneID; 618298; -.
DR   KEGG; bta:618298; -.
DR   CTD; 130827; -.
DR   VEuPathDB; HostDB:ENSBTAG00000038462; -.
DR   VGNC; VGNC:36008; TMEM182.
DR   eggNOG; ENOG502QVS4; Eukaryota.
DR   GeneTree; ENSGT00390000017581; -.
DR   HOGENOM; CLU_105472_0_0_1; -.
DR   InParanoid; A4IF75; -.
DR   OMA; WLLVTEV; -.
DR   OrthoDB; 1246131at2759; -.
DR   TreeFam; TF331344; -.
DR   Proteomes; UP000009136; Chromosome 11.
DR   Bgee; ENSBTAG00000038462; Expressed in rectus femoris and 80 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR   GO; GO:0014906; P:myotube cell development involved in skeletal muscle regeneration; ISS:UniProtKB.
DR   GO; GO:0014908; P:myotube differentiation involved in skeletal muscle regeneration; ISS:UniProtKB.
DR   GO; GO:0045662; P:negative regulation of myoblast differentiation; ISS:UniProtKB.
DR   GO; GO:1901740; P:negative regulation of myoblast fusion; ISS:UniProtKB.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   InterPro; IPR026763; TMEM182.
DR   PANTHER; PTHR32012; PTHR32012; 1.
DR   Pfam; PF13903; Claudin_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; Membrane; Myogenesis; Reference proteome;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..229
FT                   /note="Transmembrane protein 182"
FT                   /id="PRO_0000290225"
FT   TOPO_DOM        27..114
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        136..150
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        151..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        172..200
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        222..229
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          49..59
FT                   /note="Interaction with ITGB1"
FT                   /evidence="ECO:0000250|UniProtKB:A0A1D5NY17"
FT   CARBOHYD        47
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        102
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   229 AA;  25928 MW;  9F780A9CA6F5DD3F CRC64;
     MRLNIAIFFG ALFGALGVLL FLVAFGSDYW LLATEVAKCS GEQNIENVTF HHEGFFWRCW
     FNGIVEENDS NIWQFWYTNQ PLWKNCTHAY LSPYPFLRGE HNSTSYDSAV IYRGFWAVLM
     LLGVVAVVTA SFLIICAAPF TSHLLYKAGG GAYIAAGVLF ALVVMLYVIW VQAVADLESY
     RHRKMRDCLD FSPSVLYGWS FFLAPAGIFF SLLAGLLFLI VGRHIQIHH