TM182_DANRE
ID TM182_DANRE Reviewed; 248 AA.
AC Q5CZV0;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 29-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=Transmembrane protein 182;
DE Flags: Precursor;
GN Name=tmem182a; ORFNames=zgc:113334;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May negatively regulate myogenesis and skeletal muscle
CC regeneration. {ECO:0000250|UniProtKB:A0A1D5NY17}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:A0A1D5NY17};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the TMEM182 family. {ECO:0000305}.
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DR EMBL; BC090696; AAH90696.1; -; mRNA.
DR RefSeq; NP_001013338.1; NM_001013320.1.
DR AlphaFoldDB; Q5CZV0; -.
DR STRING; 7955.ENSDARP00000059091; -.
DR PaxDb; Q5CZV0; -.
DR GeneID; 503742; -.
DR KEGG; dre:503742; -.
DR CTD; 503742; -.
DR ZFIN; ZDB-GENE-050306-22; tmem182a.
DR eggNOG; ENOG502QVS4; Eukaryota.
DR InParanoid; Q5CZV0; -.
DR OrthoDB; 1246131at2759; -.
DR PhylomeDB; Q5CZV0; -.
DR PRO; PR:Q5CZV0; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR GO; GO:0014906; P:myotube cell development involved in skeletal muscle regeneration; ISS:UniProtKB.
DR GO; GO:0014908; P:myotube differentiation involved in skeletal muscle regeneration; ISS:UniProtKB.
DR GO; GO:0045662; P:negative regulation of myoblast differentiation; ISS:UniProtKB.
DR GO; GO:1901740; P:negative regulation of myoblast fusion; ISS:UniProtKB.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR InterPro; IPR026763; TMEM182.
DR PANTHER; PTHR32012; PTHR32012; 1.
DR Pfam; PF13903; Claudin_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Membrane; Myogenesis; Reference proteome;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..248
FT /note="Transmembrane protein 182"
FT /id="PRO_0000360988"
FT TOPO_DOM 27..136
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..167
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 189..218
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 219..239
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 240..248
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 66
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 119
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 212
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 248 AA; 27971 MW; 980FB39B80FBF07F CRC64;
MKIHVAGFFA GLFGALATLF ILLSFGTDYW LLASETCNSH LNSPVTSERG DILVNQVHDP
NSEAPNITFH HEGFFWRCTF DDVMNDGNLW KFWFENQPHV RVCKPAYLLP FPFPDQSYNT
TSYQTAIIYR GFWSVSMLVG VAAVVAGGFI IICAAPFASH RLYKAGGGLY LISGFFVLVV
TAMYVIWIDV LDVISLYTEY QKLNKCADFE LNKTYGLSFM FAPVGVFFCF LSGLLFLVIG
RTVHHQYN
