ID   TM182_XENTR             Reviewed;         235 AA.
AC   Q0V9E0;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Transmembrane protein 182;
DE   Flags: Precursor;
GN   Name=tmem182;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=N6; TISSUE=Skeletal muscle;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May negatively regulate myogenesis and skeletal muscle
CC       regeneration. {ECO:0000250|UniProtKB:A0A1D5NY17}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:A0A1D5NY17};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TMEM182 family. {ECO:0000305}.
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DR   EMBL; BC121614; AAI21615.1; -; mRNA.
DR   RefSeq; NP_001072403.1; NM_001078935.1.
DR   AlphaFoldDB; Q0V9E0; -.
DR   STRING; 8364.ENSXETP00000059547; -.
DR   PaxDb; Q0V9E0; -.
DR   DNASU; 779857; -.
DR   GeneID; 779857; -.
DR   KEGG; xtr:779857; -.
DR   CTD; 130827; -.
DR   Xenbase; XB-GENE-5872789; tmem182.
DR   eggNOG; ENOG502QVS4; Eukaryota.
DR   HOGENOM; CLU_105472_0_0_1; -.
DR   InParanoid; Q0V9E0; -.
DR   OrthoDB; 1246131at2759; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR   GO; GO:0014906; P:myotube cell development involved in skeletal muscle regeneration; ISS:UniProtKB.
DR   GO; GO:0014908; P:myotube differentiation involved in skeletal muscle regeneration; ISS:UniProtKB.
DR   GO; GO:0045662; P:negative regulation of myoblast differentiation; ISS:UniProtKB.
DR   GO; GO:1901740; P:negative regulation of myoblast fusion; ISS:UniProtKB.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   InterPro; IPR026763; TMEM182.
DR   PANTHER; PTHR32012; PTHR32012; 1.
DR   Pfam; PF13903; Claudin_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; Membrane; Myogenesis; Reference proteome;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..33
FT                   /evidence="ECO:0000255"
FT   CHAIN           34..235
FT                   /note="Transmembrane protein 182"
FT                   /id="PRO_0000369258"
FT   TOPO_DOM        34..122
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        123..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        144..155
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        156..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        177..205
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        206..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        227..235
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        48
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        90
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        107
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   235 AA;  26565 MW;  1FC906F4F44BBB47 CRC64;
     MKLSIGIFFG GLFGALGILI YLVAFGSDYW LLAKEIEKCS ENQETGDNAT HSVLLHHEGF
     FWRCWFNHAE EENSNTMENF WFTNQAPTKN CTHAYLSPFP QNRDNSNSTS YHSALVYRGF
     WNIFMLLGVV TAVIGGFLII CAAPFTNHRI YKAGGGLFIT SGILFALVVV MHVFWVQSVS
     DIKGYTDTRQ QDCSQFTVYV SFGWSFMLAP FGIFFCLFAG MLFLLVGHTI HVHTK