ID   TM183_BOVIN             Reviewed;         376 AA.
AC   Q5EA86; Q3T0G2;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Transmembrane protein 183;
GN   Name=TMEM183;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMEM183 family. {ECO:0000305}.
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DR   EMBL; BT020683; AAX08700.1; -; mRNA.
DR   EMBL; BC102408; AAI02409.1; -; mRNA.
DR   RefSeq; NP_001029788.1; NM_001034616.1.
DR   AlphaFoldDB; Q5EA86; -.
DR   STRING; 9913.ENSBTAP00000003726; -.
DR   PaxDb; Q5EA86; -.
DR   PRIDE; Q5EA86; -.
DR   Ensembl; ENSBTAT00000003726; ENSBTAP00000003726; ENSBTAG00000002874.
DR   GeneID; 534797; -.
DR   KEGG; bta:534797; -.
DR   CTD; 92703; -.
DR   VEuPathDB; HostDB:ENSBTAG00000002874; -.
DR   eggNOG; ENOG502QS4U; Eukaryota.
DR   GeneTree; ENSGT00390000009310; -.
DR   HOGENOM; CLU_061444_1_0_1; -.
DR   InParanoid; Q5EA86; -.
DR   OMA; DCCLLQI; -.
DR   OrthoDB; 1290599at2759; -.
DR   TreeFam; TF323300; -.
DR   Proteomes; UP000009136; Chromosome 16.
DR   Bgee; ENSBTAG00000002874; Expressed in rumen papilla and 108 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0031647; P:regulation of protein stability; IBA:GO_Central.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR026509; TMEM183.
DR   PANTHER; PTHR20988; PTHR20988; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..376
FT                   /note="Transmembrane protein 183"
FT                   /id="PRO_0000089250"
FT   TRANSMEM        300..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          97..127
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   376 AA;  42847 MW;  82D2F5A0A4BB1716 CRC64;
     MARGPGPLTR PRPDTVAMPK RGKRLKFRAQ DACSGRVTVA DYANSDPAVV RSGRVKKAVA
     NAVQQEVKSL CGLEASQVPA VEALSGAGEP CDIIDSSGET DAQEESIHER TISRKKKSKR
     HREDLNGTGG EEYPMDIWLL LASYIRPEDI VNFSLICKNA WTVTCTAAFW TRLYRRHYTL
     DASLPLRLRP ESMEKLHCLR ACVIRSLYHM YEPFAARISK NPAIPESTPS TLKNSKCLLF
     WCRKIVGNRQ EPMWEFNFKF KKQSPRLKSK CMGGLQPPIQ YEDVHTNPDQ DCCLLQVTTL
     NFIFIPIVMG MIFTLFTISV STDMRHHRVR LVFQDYPVHG GQKLRSEQGV QVILDPVHSV
     RLFDWWHPQY PFSLRA