TM183_MOUSE
ID TM183_MOUSE Reviewed; 375 AA.
AC Q9JJB9; Q3THC8; Q99LK6;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Transmembrane protein 183;
GN Name=Tmem183; Synonyms=Tmem183a; ORFNames=MNCb-2755;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RA Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.;
RT "Isolation of full-length cDNA clones from mouse brain cDNA library made by
RT oligo-capping method.";
RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and DBA/2J; TISSUE=Bone marrow, Liver, and Pancreas;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM183 family. {ECO:0000305}.
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DR EMBL; AB041592; BAA95075.1; -; mRNA.
DR EMBL; AK004922; BAB23673.1; -; mRNA.
DR EMBL; AK007779; BAB25250.1; -; mRNA.
DR EMBL; AK152852; BAE31545.1; -; mRNA.
DR EMBL; AK168331; BAE40269.1; -; mRNA.
DR EMBL; BC003210; AAH03210.1; -; mRNA.
DR CCDS; CCDS35714.1; -.
DR RefSeq; NP_001035950.1; NM_001042485.1.
DR RefSeq; NP_065613.1; NM_020588.2.
DR AlphaFoldDB; Q9JJB9; -.
DR BioGRID; 208296; 1.
DR STRING; 10090.ENSMUSP00000046786; -.
DR iPTMnet; Q9JJB9; -.
DR PhosphoSitePlus; Q9JJB9; -.
DR MaxQB; Q9JJB9; -.
DR PaxDb; Q9JJB9; -.
DR PRIDE; Q9JJB9; -.
DR ProteomicsDB; 259542; -.
DR Antibodypedia; 77926; 4 antibodies from 4 providers.
DR DNASU; 57439; -.
DR Ensembl; ENSMUST00000049470; ENSMUSP00000046786; ENSMUSG00000042305.
DR GeneID; 57439; -.
DR KEGG; mmu:57439; -.
DR UCSC; uc007crq.1; mouse.
DR CTD; 92703; -.
DR MGI; MGI:1914729; Tmem183a.
DR VEuPathDB; HostDB:ENSMUSG00000042305; -.
DR eggNOG; ENOG502QS4U; Eukaryota.
DR GeneTree; ENSGT00390000009310; -.
DR HOGENOM; CLU_061444_1_0_1; -.
DR InParanoid; Q9JJB9; -.
DR OMA; DCCLLQI; -.
DR OrthoDB; 1290599at2759; -.
DR PhylomeDB; Q9JJB9; -.
DR TreeFam; TF323300; -.
DR BioGRID-ORCS; 57439; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Tmem183a; mouse.
DR PRO; PR:Q9JJB9; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q9JJB9; protein.
DR Bgee; ENSMUSG00000042305; Expressed in prostate gland ventral lobe and 253 other tissues.
DR ExpressionAtlas; Q9JJB9; baseline and differential.
DR Genevisible; Q9JJB9; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0031647; P:regulation of protein stability; IBA:GO_Central.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR026509; TMEM183.
DR PANTHER; PTHR20988; PTHR20988; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..375
FT /note="Transmembrane protein 183"
FT /id="PRO_0000089252"
FT TRANSMEM 299..319
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 94..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 123
FT /note="Missing (in Ref. 3; AAH03210)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 375 AA; 42945 MW; 0BD0362F24229B67 CRC64;
MARGSGQLGG PHRDTVTMPK RGKRLKFRAH DACSGRVTVA DYANSDPAVV RSGRVKKAVA
NAIQQEVKSL CGLEASQVPA EEALSGVGEP CDILDSSDEM DAQEESTQER SVSRKKKSKR
HKEDPDGTGE EYPMDIWLLL ASYIRPEDIV NFSLICKNAW TVTCTAAFWT RLYRRHYTLD
ASLPLRLRPE SMEKLRCLRA CVIRSLYHMY EPFAARISKN PAIPESTPST LKNSKCLLFW
CRKIVGNRQE PMWEFNFKFK KQSPRLKSKC MERLQPPIQY QDVHTNPDQD CCLLQVTTLN
FIFIPIVMGM IFTLFTINVS TDMRHHRVRL VFQDSPVRGG QNLRSEQGVQ VVLDPVHSVR
LFDWWHPQYP FSLRA
