ID   TM183_RAT               Reviewed;         376 AA.
AC   Q68FS7;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Transmembrane protein 183;
GN   Name=Tmem183;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMEM183 family. {ECO:0000305}.
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DR   EMBL; BC079375; AAH79375.1; -; mRNA.
DR   RefSeq; NP_001013893.1; NM_001013871.1.
DR   AlphaFoldDB; Q68FS7; -.
DR   STRING; 10116.ENSRNOP00000005272; -.
DR   PaxDb; Q68FS7; -.
DR   Ensembl; ENSRNOT00000100649; ENSRNOP00000096186; ENSRNOG00000003594.
DR   GeneID; 289034; -.
DR   KEGG; rno:289034; -.
DR   UCSC; RGD:1309892; rat.
DR   CTD; 92703; -.
DR   RGD; 1309892; RGD1309892.
DR   eggNOG; ENOG502QS4U; Eukaryota.
DR   GeneTree; ENSGT00390000009310; -.
DR   HOGENOM; CLU_061444_1_0_1; -.
DR   InParanoid; Q68FS7; -.
DR   OrthoDB; 1290599at2759; -.
DR   PhylomeDB; Q68FS7; -.
DR   TreeFam; TF323300; -.
DR   PRO; PR:Q68FS7; -.
DR   Proteomes; UP000002494; Chromosome 13.
DR   Bgee; ENSRNOG00000003594; Expressed in duodenum and 19 other tissues.
DR   ExpressionAtlas; Q68FS7; baseline and differential.
DR   Genevisible; Q68FS7; RN.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0031647; P:regulation of protein stability; IBA:GO_Central.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR026509; TMEM183.
DR   PANTHER; PTHR20988; PTHR20988; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..376
FT                   /note="Transmembrane protein 183"
FT                   /id="PRO_0000089254"
FT   TRANSMEM        300..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          81..127
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   376 AA;  42982 MW;  4F912B915D1DC2A8 CRC64;
     MARGPGQLSG PRPDTVTMPK RGKRLKFRAH DACSGRVTVA DYANSDPAVV RSGRVKKAVA
     NAVQQEVKSL CGLEASQVPA EEALSGVGEP SDILDSSDEM DAQEESTQER SVSRKKKSKR
     HKEDLDGAGG EEYPMDIWLL LASYIRPEDI VNFSLICKNA WTVTCTAAFW TRLYRRHYTL
     DASLPLRLRP ESMEKLRCLR ACVIRSLYHM YEPFAARISK NPAIPESTPS TLKNSKCLLF
     WCRKIVGNRQ EPMWEFNFKF KKQSPRLKSK CMERLQPPIQ YQDVHTNPDQ DCCLLQVTTL
     NFIFIPIVMG MIFTLFTINV STDMRHHRVR LVFQDSPVRG GQHLRSEQGV QVVLDPVHSV
     RLFDWWHPQY PFSLRA