TM184_YEAST
ID TM184_YEAST Reviewed; 418 AA.
AC P36142; D6VXB2;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Transmembrane protein 184 homolog YKR051W;
GN OrderedLocusNames=YKR051W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8196765; DOI=10.1038/369371a0;
RA Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V.,
RA Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P.,
RA Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L.,
RA Daignan-Fornier B., del Rey F., Dion C., Domdey H., Duesterhoeft A.,
RA Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H.,
RA Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L.,
RA Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M.,
RA Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H.,
RA Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J.,
RA Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H.,
RA Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J.,
RA Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S.,
RA Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F.,
RA Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R.,
RA Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W.,
RA Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M.,
RA Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C.,
RA Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H.,
RA Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L.,
RA van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S.,
RA von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M.,
RA Becker I., Mewes H.-W.;
RT "Complete DNA sequence of yeast chromosome XI.";
RL Nature 369:371-378(1994).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the TMEM184 family. {ECO:0000305}.
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DR EMBL; Z28276; CAA82129.1; -; Genomic_DNA.
DR EMBL; AY692640; AAT92659.1; -; Genomic_DNA.
DR EMBL; BK006944; DAA09202.1; -; Genomic_DNA.
DR PIR; S38125; S38125.
DR RefSeq; NP_012977.3; NM_001179841.3.
DR PDB; 6AAG; X-ray; 2.44 A; A/B/C/D/E/F/G=368-389.
DR PDBsum; 6AAG; -.
DR AlphaFoldDB; P36142; -.
DR SMR; P36142; -.
DR BioGRID; 34182; 65.
DR DIP; DIP-6411N; -.
DR IntAct; P36142; 1.
DR STRING; 4932.YKR051W; -.
DR PaxDb; P36142; -.
DR PRIDE; P36142; -.
DR EnsemblFungi; YKR051W_mRNA; YKR051W; YKR051W.
DR GeneID; 853925; -.
DR KEGG; sce:YKR051W; -.
DR SGD; S000001759; YKR051W.
DR VEuPathDB; FungiDB:YKR051W; -.
DR eggNOG; KOG2641; Eukaryota.
DR GeneTree; ENSGT00940000155201; -.
DR HOGENOM; CLU_012923_4_0_1; -.
DR InParanoid; P36142; -.
DR OMA; YNLALFW; -.
DR BioCyc; YEAST:G3O-32021-MON; -.
DR PRO; PR:P36142; -.
DR Proteomes; UP000002311; Chromosome XI.
DR RNAct; P36142; protein.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:SGD.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR InterPro; IPR005178; Ostalpha/TMEM184C.
DR PANTHER; PTHR23423; PTHR23423; 1.
DR Pfam; PF03619; Solute_trans_a; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..418
FT /note="Transmembrane protein 184 homolog YKR051W"
FT /id="PRO_0000211558"
FT TOPO_DOM 1..5
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 27..43
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..78
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 100..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..168
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 190..205
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 227..246
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 268..418
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TURN 374..377
FT /evidence="ECO:0007829|PDB:6AAG"
SQ SEQUENCE 418 AA; 48757 MW; 0E78C9594E9CFDC1 CRC64;
MENKLLCWWL YWPCVYSSII ATIISFYTIT RHLLNYRKPY EQRLSIRILL LVPIFSVSCA
SGIIKPEAAQ FYVDPIREFY EAFVIYTFFT FLTLLLGGER NIITVLSLNH APTRHPIPLI
GKICKPIDLS DPFDFLFVKK GILQYVWFKP FYCFGTLICS AWKLPKFEIF LNVFYNISVT
WSLYSLALFW KCLYPELTPY KPWLKFLCVK LIIFASYWQS IIIQGLVVTG KLGTGNQDRT
SGYVYKNGLL CIEMVPFAIL HAVAFPWNKY TAFSIPYGAR MKFIYALKDF LGCGDLIWDF
KQTLFAGPLY YNYRNFDPEA MDLLSTRQQS GATMERLKHG LRFTDNGRNS YWVAYGSIDN
NLVPESIEES WEDDIAGQRT FPEDPNYPVV HDYTMGHRYS RSMNDLRRDV QSRSSMAC
