TM186_DANRE
ID TM186_DANRE Reviewed; 228 AA.
AC B3DI94;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 1.
DT 03-AUG-2022, entry version 58.
DE RecName: Full=Transmembrane protein 186 {ECO:0000250|UniProtKB:Q96B77};
GN Name=tmem186 {ECO:0000250|UniProtKB:Q96B77};
GN ORFNames=zgc:194533, zgc:194539;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be required for efficient assembly of the mitochondrial
CC complex I. {ECO:0000250|UniProtKB:Q96B77}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q96B77}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q96B77}.
CC -!- SIMILARITY: Belongs to the TMEM186 family. {ECO:0000305}.
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DR EMBL; BC163045; AAI63045.1; -; mRNA.
DR EMBL; BC163049; AAI63049.1; -; mRNA.
DR RefSeq; NP_001129456.1; NM_001135984.1.
DR AlphaFoldDB; B3DI94; -.
DR STRING; 7955.ENSDARP00000103823; -.
DR PaxDb; B3DI94; -.
DR PeptideAtlas; B3DI94; -.
DR Ensembl; ENSDART00000182487; ENSDARP00000156317; ENSDARG00000109974.
DR GeneID; 799142; -.
DR KEGG; dre:799142; -.
DR CTD; 25880; -.
DR ZFIN; ZDB-GENE-081022-122; tmem186.
DR eggNOG; ENOG502S11D; Eukaryota.
DR GeneTree; ENSGT00390000000087; -.
DR HOGENOM; CLU_104872_2_0_1; -.
DR InParanoid; B3DI94; -.
DR OMA; MTIGDTG; -.
DR OrthoDB; 1296527at2759; -.
DR PhylomeDB; B3DI94; -.
DR TreeFam; TF326623; -.
DR Reactome; R-DRE-611105; Respiratory electron transport.
DR Reactome; R-DRE-6799198; Complex I biogenesis.
DR PRO; PR:B3DI94; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 22.
DR Bgee; ENSDARG00000109974; Expressed in tail and 8 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR026571; Tmem186.
DR InterPro; IPR045325; TMEM70/TMEM186/TMEM223.
DR PANTHER; PTHR13603; PTHR13603; 1.
DR Pfam; PF06979; TMEM70; 1.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..228
FT /note="Transmembrane protein 186"
FT /id="PRO_0000359594"
FT TOPO_DOM 1..93
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000305"
FT TRANSMEM 94..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 113..118
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000305"
FT TRANSMEM 119..141
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 142..228
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000305"
SQ SEQUENCE 228 AA; 25720 MW; 3D692D5045EF98E5 CRC64;
MDMMMMSTRL IHLSRHFPQY GFRCHPSGLI SSARMQYNIN NGLAHMGKQM PNTSTHTTRI
HPASFSSDLA SRKYSLIYAF PLIRGLRALS RLKLLQTGIT VVLLPTVYYL HLQGQASVLV
LNRSIGIALF AGVMLYSISH FVRRVVGMMY LDSTQTILKV SHLSFWGHRR DIYVPVSDVV
TLGDSGDSRG ESILRLKRYS TSNTMYFSTR LGRVVDRHAF GKVFGSLS