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TM186_DANRE
ID   TM186_DANRE             Reviewed;         228 AA.
AC   B3DI94;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Transmembrane protein 186 {ECO:0000250|UniProtKB:Q96B77};
GN   Name=tmem186 {ECO:0000250|UniProtKB:Q96B77};
GN   ORFNames=zgc:194533, zgc:194539;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be required for efficient assembly of the mitochondrial
CC       complex I. {ECO:0000250|UniProtKB:Q96B77}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q96B77}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q96B77}.
CC   -!- SIMILARITY: Belongs to the TMEM186 family. {ECO:0000305}.
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DR   EMBL; BC163045; AAI63045.1; -; mRNA.
DR   EMBL; BC163049; AAI63049.1; -; mRNA.
DR   RefSeq; NP_001129456.1; NM_001135984.1.
DR   AlphaFoldDB; B3DI94; -.
DR   STRING; 7955.ENSDARP00000103823; -.
DR   PaxDb; B3DI94; -.
DR   PeptideAtlas; B3DI94; -.
DR   Ensembl; ENSDART00000182487; ENSDARP00000156317; ENSDARG00000109974.
DR   GeneID; 799142; -.
DR   KEGG; dre:799142; -.
DR   CTD; 25880; -.
DR   ZFIN; ZDB-GENE-081022-122; tmem186.
DR   eggNOG; ENOG502S11D; Eukaryota.
DR   GeneTree; ENSGT00390000000087; -.
DR   HOGENOM; CLU_104872_2_0_1; -.
DR   InParanoid; B3DI94; -.
DR   OMA; MTIGDTG; -.
DR   OrthoDB; 1296527at2759; -.
DR   PhylomeDB; B3DI94; -.
DR   TreeFam; TF326623; -.
DR   Reactome; R-DRE-611105; Respiratory electron transport.
DR   Reactome; R-DRE-6799198; Complex I biogenesis.
DR   PRO; PR:B3DI94; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 22.
DR   Bgee; ENSDARG00000109974; Expressed in tail and 8 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR   InterPro; IPR026571; Tmem186.
DR   InterPro; IPR045325; TMEM70/TMEM186/TMEM223.
DR   PANTHER; PTHR13603; PTHR13603; 1.
DR   Pfam; PF06979; TMEM70; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..228
FT                   /note="Transmembrane protein 186"
FT                   /id="PRO_0000359594"
FT   TOPO_DOM        1..93
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        94..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        113..118
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        119..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        142..228
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   228 AA;  25720 MW;  3D692D5045EF98E5 CRC64;
     MDMMMMSTRL IHLSRHFPQY GFRCHPSGLI SSARMQYNIN NGLAHMGKQM PNTSTHTTRI
     HPASFSSDLA SRKYSLIYAF PLIRGLRALS RLKLLQTGIT VVLLPTVYYL HLQGQASVLV
     LNRSIGIALF AGVMLYSISH FVRRVVGMMY LDSTQTILKV SHLSFWGHRR DIYVPVSDVV
     TLGDSGDSRG ESILRLKRYS TSNTMYFSTR LGRVVDRHAF GKVFGSLS
 
 
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