TM186_RAT
ID TM186_RAT Reviewed; 216 AA.
AC Q4KLZ1;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2005, sequence version 1.
DT 03-AUG-2022, entry version 71.
DE RecName: Full=Transmembrane protein 186 {ECO:0000305};
GN Name=Tmem186 {ECO:0000312|RGD:1561167};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: As part of the MCIA complex, required for efficient assembly
CC of the mitochondrial complex I. {ECO:0000250|UniProtKB:Q96B77}.
CC -!- SUBUNIT: Part of the mitochondrial complex I assembly/MCIA complex that
CC comprises at least the core subunits TMEM126B, NDUFAF1, ECSIT and ACAD9
CC and complement subunits such as COA1 and TMEM186. Interacts with MT-
CC ND3. {ECO:0000250|UniProtKB:Q96B77}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q96B77}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q96B77}.
CC -!- SIMILARITY: Belongs to the TMEM186 family. {ECO:0000305}.
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DR EMBL; BC098933; AAH98933.1; -; mRNA.
DR RefSeq; NP_001020927.1; NM_001025756.1.
DR AlphaFoldDB; Q4KLZ1; -.
DR STRING; 10116.ENSRNOP00000062154; -.
DR iPTMnet; Q4KLZ1; -.
DR PhosphoSitePlus; Q4KLZ1; -.
DR PaxDb; Q4KLZ1; -.
DR Ensembl; ENSRNOT00000030290; ENSRNOP00000062154; ENSRNOG00000027087.
DR GeneID; 497863; -.
DR KEGG; rno:497863; -.
DR UCSC; RGD:1561167; rat.
DR CTD; 25880; -.
DR RGD; 1561167; Tmem186.
DR eggNOG; ENOG502S11D; Eukaryota.
DR GeneTree; ENSGT00390000000087; -.
DR HOGENOM; CLU_104872_1_0_1; -.
DR InParanoid; Q4KLZ1; -.
DR OMA; MTIGDTG; -.
DR OrthoDB; 1296527at2759; -.
DR PhylomeDB; Q4KLZ1; -.
DR TreeFam; TF326623; -.
DR Reactome; R-RNO-611105; Respiratory electron transport.
DR Reactome; R-RNO-6799198; Complex I biogenesis.
DR PRO; PR:Q4KLZ1; -.
DR Proteomes; UP000002494; Chromosome 10.
DR Bgee; ENSRNOG00000027087; Expressed in skeletal muscle tissue and 19 other tissues.
DR Genevisible; Q4KLZ1; RN.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR026571; Tmem186.
DR PANTHER; PTHR13603; PTHR13603; 1.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..216
FT /note="Transmembrane protein 186"
FT /id="PRO_0000279441"
FT TOPO_DOM 1..68
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000305"
FT TRANSMEM 69..91
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 92..103
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000305"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 125..216
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000305"
SQ SEQUENCE 216 AA; 24641 MW; 114C413E8A3429DA CRC64;
MAFLLRAVPR LQGPAAWRRP LQQLWCRAGQ GDSIRWVGSR SPPSQEKPPG TETEKFHTIY
RFNAIRALGF LSRLKLAQTA VTVVALPPGF YCYSQGLMTL SSLGLMSGIA SFALVMLCWM
SHFFRRLVGI LYVNESGTLL RVAHLTFWGW RQDTYCAVSD MIPLSESEER VQDVFVRIQQ
YSGKQTFYLT LRYGRILDRD RFSQVFGTLA TLKNSK
