TM187_HUMAN
ID TM187_HUMAN Reviewed; 261 AA.
AC Q14656; B2RC47; Q6IAV7;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Transmembrane protein 187;
DE AltName: Full=Protein ITBA1;
GN Name=TMEM187; Synonyms=CXorf12, DXS9878E, ITBA1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Skeletal muscle;
RX PubMed=8786131; DOI=10.1006/geno.1996.0293;
RA Faranda S., Frattini A., Zucchi I., Patrosso C., Milanesi L., Montagna C.,
RA Vezzoni P.;
RT "Characterization and fine localization of two new genes in Xq28 using the
RT genomic sequence/EST database screening approach.";
RL Genomics 34:323-327(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q14656; Q3SXY8: ARL13B; NbExp=3; IntAct=EBI-13046724, EBI-11343438;
CC Q14656; P11912: CD79A; NbExp=3; IntAct=EBI-13046724, EBI-7797864;
CC Q14656; Q99675: CGRRF1; NbExp=3; IntAct=EBI-13046724, EBI-2130213;
CC Q14656; Q8N5K1: CISD2; NbExp=3; IntAct=EBI-13046724, EBI-1045797;
CC Q14656; P21964: COMT; NbExp=3; IntAct=EBI-13046724, EBI-372265;
CC Q14656; Q96KR6: FAM210B; NbExp=3; IntAct=EBI-13046724, EBI-18938272;
CC Q14656; Q5T7V8: GORAB; NbExp=3; IntAct=EBI-13046724, EBI-3917143;
CC Q14656; A8MZ59: LEUTX; NbExp=3; IntAct=EBI-13046724, EBI-17490413;
CC Q14656; P15941-11: MUC1; NbExp=3; IntAct=EBI-13046724, EBI-17263240;
CC Q14656; O15173: PGRMC2; NbExp=3; IntAct=EBI-13046724, EBI-1050125;
CC Q14656; Q9NR31: SAR1A; NbExp=3; IntAct=EBI-13046724, EBI-3920694;
CC Q14656; Q9NPE6: SPAG4; NbExp=3; IntAct=EBI-13046724, EBI-10819434;
CC Q14656; Q9NYW4: TAS2R5; NbExp=3; IntAct=EBI-13046724, EBI-17933167;
CC Q14656; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-13046724, EBI-8638294;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Ubiquitous.
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DR EMBL; X92475; CAA63213.1; -; mRNA.
DR EMBL; AK314938; BAG37444.1; -; mRNA.
DR EMBL; CH471172; EAW72766.1; -; Genomic_DNA.
DR EMBL; BC008203; AAH08203.1; -; mRNA.
DR EMBL; BC017026; AAH17026.1; -; mRNA.
DR EMBL; CR457047; CAG33328.1; -; mRNA.
DR CCDS; CCDS14739.1; -.
DR RefSeq; NP_003483.1; NM_003492.2.
DR RefSeq; XP_011529501.1; XM_011531199.2.
DR AlphaFoldDB; Q14656; -.
DR BioGRID; 113887; 15.
DR IntAct; Q14656; 16.
DR MINT; Q14656; -.
DR STRING; 9606.ENSP00000358999; -.
DR TCDB; 9.B.360.1.1; the autism-related tmem187 (tmem187) family.
DR BioMuta; TMEM187; -.
DR DMDM; 2498474; -.
DR MassIVE; Q14656; -.
DR PaxDb; Q14656; -.
DR PeptideAtlas; Q14656; -.
DR PRIDE; Q14656; -.
DR Antibodypedia; 31098; 27 antibodies from 12 providers.
DR DNASU; 8269; -.
DR Ensembl; ENST00000369982.5; ENSP00000358999.4; ENSG00000177854.8.
DR GeneID; 8269; -.
DR KEGG; hsa:8269; -.
DR MANE-Select; ENST00000369982.5; ENSP00000358999.4; NM_003492.3; NP_003483.1.
DR UCSC; uc004fjq.3; human.
DR CTD; 8269; -.
DR DisGeNET; 8269; -.
DR GeneCards; TMEM187; -.
DR HGNC; HGNC:13705; TMEM187.
DR HPA; ENSG00000177854; Low tissue specificity.
DR MIM; 300059; gene.
DR neXtProt; NX_Q14656; -.
DR OpenTargets; ENSG00000177854; -.
DR PharmGKB; PA162406199; -.
DR VEuPathDB; HostDB:ENSG00000177854; -.
DR eggNOG; ENOG502QUS7; Eukaryota.
DR GeneTree; ENSGT00390000011272; -.
DR HOGENOM; CLU_093204_0_0_1; -.
DR InParanoid; Q14656; -.
DR OMA; FLAMPCN; -.
DR OrthoDB; 1348522at2759; -.
DR PhylomeDB; Q14656; -.
DR TreeFam; TF353833; -.
DR PathwayCommons; Q14656; -.
DR SignaLink; Q14656; -.
DR BioGRID-ORCS; 8269; 7 hits in 707 CRISPR screens.
DR ChiTaRS; TMEM187; human.
DR GenomeRNAi; 8269; -.
DR Pharos; Q14656; Tdark.
DR PRO; PR:Q14656; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q14656; protein.
DR Bgee; ENSG00000177854; Expressed in endometrium epithelium and 164 other tissues.
DR ExpressionAtlas; Q14656; baseline and differential.
DR Genevisible; Q14656; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030133; C:transport vesicle; IDA:LIFEdb.
DR InterPro; IPR028066; TMEM187.
DR PANTHER; PTHR15066; PTHR15066; 1.
DR Pfam; PF15100; TMEM187; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..261
FT /note="Transmembrane protein 187"
FT /id="PRO_0000084262"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..162
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..210
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 70
FT /note="S -> L (in dbSNP:rs2266890)"
FT /id="VAR_051431"
FT VARIANT 78
FT /note="M -> V (in dbSNP:rs7350355)"
FT /id="VAR_051432"
FT VARIANT 138
FT /note="R -> Q (in dbSNP:rs36085378)"
FT /id="VAR_051433"
FT CONFLICT 37
FT /note="Y -> C (in Ref. 2; CAG33328)"
FT /evidence="ECO:0000305"
FT CONFLICT 131
FT /note="L -> F (in Ref. 2; CAG33328)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 261 AA; 29148 MW; 736265D26A32C380 CRC64;
MNPEWGQAFV HVAVAGGLCA VAVFTGIFDS VSVQVGYEHY AEAPVAGLPA FLAMPFNSLV
NMAYTLLGLS WLHRGGAMGL GPRYLKDVFA AMALLYGPVQ WLRLWTQWRR AAVLDQWLTL
PIFAWPVAWC LYLDRGWRPW LFLSLECVSL ASYGLALLHP QGFEVALGAH VVAAVGQALR
THRHYGSTTS ATYLALGVLS CLGFVVLKLC DHQLARWRLF QCLTGHFWSK VCDVLQFHFA
FLFLTHFNTH PRFHPSGGKT R
