ID   TM190_BOVIN             Reviewed;         180 AA.
AC   E1BJD3;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   02-NOV-2010, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Transmembrane protein 190;
DE   Flags: Precursor;
GN   Name=TMEM190;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=19390049; DOI=10.1126/science.1169588;
RG   The bovine genome sequencing and analysis consortium;
RT   "The genome sequence of taurine cattle: a window to ruminant biology and
RT   evolution.";
RL   Science 324:522-528(2009).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}.
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DR   EMBL; AAFC03089057; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001192488.1; NM_001205559.1.
DR   AlphaFoldDB; E1BJD3; -.
DR   STRING; 9913.ENSBTAP00000028044; -.
DR   PaxDb; E1BJD3; -.
DR   Ensembl; ENSBTAT00000028044; ENSBTAP00000028044; ENSBTAG00000021057.
DR   GeneID; 504932; -.
DR   KEGG; bta:504932; -.
DR   CTD; 147744; -.
DR   VEuPathDB; HostDB:ENSBTAG00000021057; -.
DR   VGNC; VGNC:36016; TMEM190.
DR   eggNOG; ENOG502T0Q7; Eukaryota.
DR   GeneTree; ENSGT00390000006710; -.
DR   HOGENOM; CLU_130475_0_0_1; -.
DR   InParanoid; E1BJD3; -.
DR   OrthoDB; 1323569at2759; -.
DR   TreeFam; TF337652; -.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000021057; Expressed in dorsal thalamus and 76 other tissues.
DR   ExpressionAtlas; E1BJD3; baseline and differential.
DR   GO; GO:0002079; C:inner acrosomal membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IBA:GO_Central.
DR   InterPro; IPR044913; P_trefoil_dom_sf.
DR   InterPro; IPR028248; TMEM190.
DR   PANTHER; PTHR37868; PTHR37868; 1.
DR   Pfam; PF15431; TMEM190; 1.
DR   SUPFAM; SSF57492; SSF57492; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..180
FT                   /note="Transmembrane protein 190"
FT                   /id="PRO_0000406753"
FT   TOPO_DOM        22..81
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        103..180
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          31..71
FT                   /note="P-type"
FT   REGION          131..180
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        33..61
FT                   /evidence="ECO:0000250"
FT   DISULFID        43..60
FT                   /evidence="ECO:0000250"
FT   DISULFID        55..67
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   180 AA;  19743 MW;  C47E23BDF0D27889 CRC64;
     MVGSGIPALG LLLLMQGSAD GNGIQGFFYP WSCEGDVWDR ESCGGQAAIE NPNLCLRLRC
     CYRDGVCYHQ RPDENMRRKH MWALGWTCGG LLFLITSICL FWWARRHDML RLPWFLKGKC
     DLSRTVSLLS KDRTPSEKKT PSVGSIPPAA PTEGALDVSG GTEGEGTEGG EETEGGDEDD