TM190_CANLF
ID TM190_CANLF Reviewed; 181 AA.
AC E2R0A5;
DT 05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 1.
DT 03-AUG-2022, entry version 54.
DE RecName: Full=Transmembrane protein 190;
DE Flags: Precursor;
GN Name=TMEM190;
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Boxer;
RX PubMed=16341006; DOI=10.1038/nature04338;
RA Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
RA Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., Mauceli E.,
RA Xie X., Breen M., Wayne R.K., Ostrander E.A., Ponting C.P., Galibert F.,
RA Smith D.R., deJong P.J., Kirkness E.F., Alvarez P., Biagi T., Brockman W.,
RA Butler J., Chin C.-W., Cook A., Cuff J., Daly M.J., DeCaprio D., Gnerre S.,
RA Grabherr M., Kellis M., Kleber M., Bardeleben C., Goodstadt L., Heger A.,
RA Hitte C., Kim L., Koepfli K.-P., Parker H.G., Pollinger J.P.,
RA Searle S.M.J., Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
RA Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
RA Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., Bachantsang P.,
RA Barry A., Bayul T., Benamara M., Berlin A., Bessette D., Blitshteyn B.,
RA Bloom T., Blye J., Boguslavskiy L., Bonnet C., Boukhgalter B., Brown A.,
RA Cahill P., Calixte N., Camarata J., Cheshatsang Y., Chu J., Citroen M.,
RA Collymore A., Cooke P., Dawoe T., Daza R., Decktor K., DeGray S.,
RA Dhargay N., Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L.,
RA Duffey N., Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
RA Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., Foley C.,
RA Franke A., Friedrich D., Gage D., Garber M., Gearin G., Giannoukos G.,
RA Goode T., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N.,
RA Hagopian D., Hagos B., Hall J., Healy C., Hegarty R., Honan T., Horn A.,
RA Houde N., Hughes L., Hunnicutt L., Husby M., Jester B., Jones C., Kamat A.,
RA Kanga B., Kells C., Khazanovich D., Kieu A.C., Kisner P., Kumar M.,
RA Lance K., Landers T., Lara M., Lee W., Leger J.-P., Lennon N., Leuper L.,
RA LeVine S., Liu J., Liu X., Lokyitsang Y., Lokyitsang T., Lui A.,
RA Macdonald J., Major J., Marabella R., Maru K., Matthews C., McDonough S.,
RA Mehta T., Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T.,
RA Miller K., Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A.,
RA Naylor J., Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
RA Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., Osman S.,
RA Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., Priest M.,
RA Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., Rege F.,
RA Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., Sharpe T.,
RA Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., Smith C.,
RA Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C.,
RA Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., Thoulutsang D.,
RA Thoulutsang Y., Topham K., Topping I., Tsamla T., Vassiliev H.,
RA Venkataraman V., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA Wilson A., Yadav S., Yang S., Yang X., Young G., Yu Q., Zainoun J.,
RA Zembek L., Zimmer A., Lander E.S.;
RT "Genome sequence, comparative analysis and haplotype structure of the
RT domestic dog.";
RL Nature 438:803-819(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
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DR RefSeq; NP_001300704.1; NM_001313775.1.
DR AlphaFoldDB; E2R0A5; -.
DR STRING; 9612.ENSCAFP00000003759; -.
DR PaxDb; E2R0A5; -.
DR PRIDE; E2R0A5; -.
DR Ensembl; ENSCAFT00030001545; ENSCAFP00030001371; ENSCAFG00030000904.
DR Ensembl; ENSCAFT00040014669; ENSCAFP00040012687; ENSCAFG00040007881.
DR Ensembl; ENSCAFT00845001619; ENSCAFP00845001281; ENSCAFG00845000949.
DR GeneID; 476379; -.
DR KEGG; cfa:476379; -.
DR CTD; 147744; -.
DR VEuPathDB; HostDB:ENSCAFG00845000949; -.
DR eggNOG; ENOG502T0Q7; Eukaryota.
DR GeneTree; ENSGT00390000006710; -.
DR HOGENOM; CLU_130475_0_0_1; -.
DR InParanoid; E2R0A5; -.
DR OMA; SSICLFW; -.
DR OrthoDB; 1323569at2759; -.
DR TreeFam; TF337652; -.
DR Proteomes; UP000002254; Chromosome 1.
DR Bgee; ENSCAFG00000002587; Expressed in testis and 39 other tissues.
DR GO; GO:0002079; C:inner acrosomal membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043621; F:protein self-association; IEA:Ensembl.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IBA:GO_Central.
DR InterPro; IPR044913; P_trefoil_dom_sf.
DR InterPro; IPR028248; TMEM190.
DR PANTHER; PTHR37868; PTHR37868; 1.
DR Pfam; PF15431; TMEM190; 1.
DR SUPFAM; SSF57492; SSF57492; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..181
FT /note="Transmembrane protein 190"
FT /id="PRO_0000406754"
FT TOPO_DOM 22..81
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..181
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 31..71
FT /note="P-type"
FT REGION 135..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..156
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 33..61
FT /evidence="ECO:0000250"
FT DISULFID 43..60
FT /evidence="ECO:0000250"
FT DISULFID 55..67
FT /evidence="ECO:0000250"
SQ SEQUENCE 181 AA; 19777 MW; D393FD3E59FFD258 CRC64;
MVASGIPALS LFLLMQGSVD GNGIQGFFYP WSCEGDVWDR ESCGGQAAIE NPNLCLRLRC
CYRDGVCYHQ RPDETMRRKH MWALGWTCGG LLFLISSICL FWWAKRRDML HLPGFLKGKC
DLSRTVSLLS KDRGTLSDKK TSAGSVPTSL PTEGNADVSG ATEGEGTTEG GEETEGGEDE
D
