TM190_HUMAN
ID TM190_HUMAN Reviewed; 177 AA.
AC Q8WZ59; A6NJL5;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Transmembrane protein 190;
DE Flags: Precursor;
GN Name=TMEM190; Synonyms=MDAC1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Gong L., Wu K.;
RT "Identification of MDAC1, a novel gene located on human chromosome 19.";
RL Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8WZ59; Q3SXY8: ARL13B; NbExp=3; IntAct=EBI-10278423, EBI-11343438;
CC Q8WZ59; Q07108: CD69; NbExp=6; IntAct=EBI-10278423, EBI-2836595;
CC Q8WZ59; O00501: CLDN5; NbExp=3; IntAct=EBI-10278423, EBI-18400628;
CC Q8WZ59; Q9UHP7-3: CLEC2D; NbExp=3; IntAct=EBI-10278423, EBI-11749983;
CC Q8WZ59; P0C7H8: KRTAP2-3; NbExp=3; IntAct=EBI-10278423, EBI-10196781;
CC Q8WZ59; Q6L8G4: KRTAP5-11; NbExp=3; IntAct=EBI-10278423, EBI-11993296;
CC Q8WZ59; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-10278423, EBI-1044640;
CC Q8WZ59; Q5T700: LDLRAD1; NbExp=7; IntAct=EBI-10278423, EBI-10173166;
CC Q8WZ59; Q8N5G2: MACO1; NbExp=3; IntAct=EBI-10278423, EBI-2683507;
CC Q8WZ59; Q9H8S9: MOB1A; NbExp=3; IntAct=EBI-10278423, EBI-748229;
CC Q8WZ59; O43278-2: SPINT1; NbExp=3; IntAct=EBI-10278423, EBI-12078338;
CC Q8WZ59; Q8N6K0: TEX29; NbExp=3; IntAct=EBI-10278423, EBI-19027521;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF442729; AAL35294.1; -; mRNA.
DR EMBL; AC020922; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471135; EAW72372.1; -; Genomic_DNA.
DR EMBL; BC128189; AAI28190.1; -; mRNA.
DR EMBL; BC128190; AAI28191.1; -; mRNA.
DR CCDS; CCDS33113.1; -.
DR RefSeq; NP_631911.1; NM_139172.2.
DR AlphaFoldDB; Q8WZ59; -.
DR BioGRID; 127085; 12.
DR IntAct; Q8WZ59; 12.
DR STRING; 9606.ENSP00000291934; -.
DR iPTMnet; Q8WZ59; -.
DR PhosphoSitePlus; Q8WZ59; -.
DR BioMuta; TMEM190; -.
DR DMDM; 74716581; -.
DR EPD; Q8WZ59; -.
DR MassIVE; Q8WZ59; -.
DR PaxDb; Q8WZ59; -.
DR PeptideAtlas; Q8WZ59; -.
DR PRIDE; Q8WZ59; -.
DR ProteomicsDB; 75221; -.
DR Antibodypedia; 19561; 18 antibodies from 14 providers.
DR DNASU; 147744; -.
DR Ensembl; ENST00000291934.4; ENSP00000291934.3; ENSG00000160472.5.
DR GeneID; 147744; -.
DR KEGG; hsa:147744; -.
DR MANE-Select; ENST00000291934.4; ENSP00000291934.3; NM_139172.3; NP_631911.1.
DR UCSC; uc002qkt.1; human.
DR CTD; 147744; -.
DR DisGeNET; 147744; -.
DR GeneCards; TMEM190; -.
DR HGNC; HGNC:29632; TMEM190.
DR HPA; ENSG00000160472; Group enriched (fallopian tube, testis).
DR neXtProt; NX_Q8WZ59; -.
DR OpenTargets; ENSG00000160472; -.
DR PharmGKB; PA162406247; -.
DR VEuPathDB; HostDB:ENSG00000160472; -.
DR eggNOG; ENOG502T0Q7; Eukaryota.
DR GeneTree; ENSGT00390000006710; -.
DR HOGENOM; CLU_130475_0_0_1; -.
DR InParanoid; Q8WZ59; -.
DR OMA; SSICLFW; -.
DR OrthoDB; 1323569at2759; -.
DR PhylomeDB; Q8WZ59; -.
DR TreeFam; TF337652; -.
DR PathwayCommons; Q8WZ59; -.
DR SignaLink; Q8WZ59; -.
DR BioGRID-ORCS; 147744; 16 hits in 1072 CRISPR screens.
DR GenomeRNAi; 147744; -.
DR Pharos; Q8WZ59; Tdark.
DR PRO; PR:Q8WZ59; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8WZ59; protein.
DR Bgee; ENSG00000160472; Expressed in right uterine tube and 107 other tissues.
DR Genevisible; Q8WZ59; HS.
DR GO; GO:0002079; C:inner acrosomal membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; HDA:UniProtKB.
DR GO; GO:0043621; F:protein self-association; IEA:Ensembl.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IBA:GO_Central.
DR InterPro; IPR044913; P_trefoil_dom_sf.
DR InterPro; IPR028248; TMEM190.
DR PANTHER; PTHR37868; PTHR37868; 1.
DR Pfam; PF15431; TMEM190; 1.
DR SUPFAM; SSF57492; SSF57492; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..177
FT /note="Transmembrane protein 190"
FT /id="PRO_0000312282"
FT TOPO_DOM 22..81
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..177
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 31..71
FT /note="P-type"
FT REGION 131..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..177
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 33..61
FT /evidence="ECO:0000250"
FT DISULFID 43..60
FT /evidence="ECO:0000250"
FT DISULFID 55..67
FT /evidence="ECO:0000250"
SQ SEQUENCE 177 AA; 19457 MW; 618E843FFE8FC511 CRC64;
MLGCGIPALG LLLLLQGSAD GNGIQGFFYP WSCEGDIWDR ESCGGQAAID SPNLCLRLRC
CYRNGVCYHQ RPDENVRRKH MWALVWTCSG LLLLSCSICL FWWAKRRDVL HMPGFLAGPC
DMSKSVSLLS KHRGTKKTPS TGSVPVALSK ESRDVEGGTE GEGTEEGEET EGEEEED
