ID   TM192_DANRE             Reviewed;         271 AA.
AC   Q6NYE7; A7E2K3;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Transmembrane protein 192;
GN   Name=tmem192; ORFNames=zgc:77068;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney, and Larval eye;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q8IY95};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8IY95}. Late
CC       endosome {ECO:0000250|UniProtKB:Q8IY95}.
CC   -!- SIMILARITY: Belongs to the TMEM192 family. {ECO:0000305}.
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DR   EMBL; BC066623; AAH66623.1; -; mRNA.
DR   EMBL; BC150390; AAI50391.1; -; mRNA.
DR   RefSeq; NP_001095863.1; NM_001102393.1.
DR   AlphaFoldDB; Q6NYE7; -.
DR   SMR; Q6NYE7; -.
DR   STRING; 7955.ENSDARP00000054574; -.
DR   PaxDb; Q6NYE7; -.
DR   PRIDE; Q6NYE7; -.
DR   GeneID; 797335; -.
DR   KEGG; dre:797335; -.
DR   CTD; 201931; -.
DR   ZFIN; ZDB-GENE-040426-2254; tmem192.
DR   eggNOG; ENOG502RYVA; Eukaryota.
DR   InParanoid; Q6NYE7; -.
DR   OrthoDB; 1249559at2759; -.
DR   PhylomeDB; Q6NYE7; -.
DR   PRO; PR:Q6NYE7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005770; C:late endosome; IBA:GO_Central.
DR   GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR   InterPro; IPR029399; TMEM192.
DR   PANTHER; PTHR31592; PTHR31592; 1.
DR   Pfam; PF14802; TMEM192; 1.
PE   2: Evidence at transcript level;
KW   Endosome; Lysosome; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..271
FT                   /note="Transmembrane protein 192"
FT                   /id="PRO_0000311271"
FT   TRANSMEM        56..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        145..165
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          209..234
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        33
FT                   /note="L -> P (in Ref. 1; AAI50391)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        136
FT                   /note="M -> T (in Ref. 1; AAI50391)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        167
FT                   /note="A -> T (in Ref. 1; AAI50391)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   271 AA;  30209 MW;  C381D53C113EFD56 CRC64;
     MVMESGRTSA YGNNTNVDFT QSTDDDPLID GPLVSQDALE SAIKREFQTL STHWAVGVLS
     FLHVVYVVVC IVITVFCWIS DEHTSECTAA LNGIDSKTVV LLGKVALWVV VFIYDRVVQR
     RHSAVRRKGY LDFYRMTKGI KSLPLLIHSA GNAAILTVIA PSSLLDANVK NLSVYLLLAI
     ICLELLLTII CLLRYTVHVV KFNRKKPHPD VTEEERSYGC SSDAHTETGF RDGSSLEDVV
     EKQADLIDYL KQHNSVLSRR ILTLTGQQIR A