TM192_MOUSE
ID TM192_MOUSE Reviewed; 266 AA.
AC Q9CXT7; Q3THT5; Q8VDU8;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Transmembrane protein 192;
GN Name=Tmem192;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=BALB/cJ, and C57BL/6J; TISSUE=Corpora quadrigemina, and Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q8IY95};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8IY95}. Late
CC endosome {ECO:0000250|UniProtKB:Q8IY95}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9CXT7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9CXT7-2; Sequence=VSP_029503;
CC -!- SIMILARITY: Belongs to the TMEM192 family. {ECO:0000305}.
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DR EMBL; AK013998; BAB29107.1; -; mRNA.
DR EMBL; AK046181; BAC32622.1; -; mRNA.
DR EMBL; AK168146; BAE40111.1; -; mRNA.
DR EMBL; BC020157; AAH20157.1; -; mRNA.
DR CCDS; CCDS22329.1; -. [Q9CXT7-1]
DR CCDS; CCDS52559.1; -. [Q9CXT7-2]
DR RefSeq; NP_001157219.1; NM_001163747.1. [Q9CXT7-2]
DR RefSeq; NP_082703.1; NM_028427.3. [Q9CXT7-1]
DR AlphaFoldDB; Q9CXT7; -.
DR SMR; Q9CXT7; -.
DR iPTMnet; Q9CXT7; -.
DR PhosphoSitePlus; Q9CXT7; -.
DR EPD; Q9CXT7; -.
DR MaxQB; Q9CXT7; -.
DR PaxDb; Q9CXT7; -.
DR PeptideAtlas; Q9CXT7; -.
DR PRIDE; Q9CXT7; -.
DR ProteomicsDB; 259219; -. [Q9CXT7-1]
DR ProteomicsDB; 259220; -. [Q9CXT7-2]
DR Antibodypedia; 7685; 89 antibodies from 23 providers.
DR Ensembl; ENSMUST00000026595; ENSMUSP00000026595; ENSMUSG00000025521. [Q9CXT7-1]
DR Ensembl; ENSMUST00000079896; ENSMUSP00000078819; ENSMUSG00000025521. [Q9CXT7-2]
DR GeneID; 73067; -.
DR KEGG; mmu:73067; -.
DR UCSC; uc009lvb.3; mouse. [Q9CXT7-1]
DR UCSC; uc009lvc.3; mouse. [Q9CXT7-2]
DR CTD; 201931; -.
DR MGI; MGI:1920317; Tmem192.
DR VEuPathDB; HostDB:ENSMUSG00000025521; -.
DR eggNOG; ENOG502QWR8; Eukaryota.
DR GeneTree; ENSGT00390000013749; -.
DR HOGENOM; CLU_086771_0_0_1; -.
DR InParanoid; Q9CXT7; -.
DR OMA; RCEAYFI; -.
DR OrthoDB; 1249559at2759; -.
DR PhylomeDB; Q9CXT7; -.
DR TreeFam; TF323773; -.
DR BioGRID-ORCS; 73067; 5 hits in 72 CRISPR screens.
DR PRO; PR:Q9CXT7; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q9CXT7; protein.
DR Bgee; ENSMUSG00000025521; Expressed in right kidney and 228 other tissues.
DR ExpressionAtlas; Q9CXT7; baseline and differential.
DR Genevisible; Q9CXT7; MM.
DR GO; GO:0005768; C:endosome; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005770; C:late endosome; ISO:MGI.
DR GO; GO:0005765; C:lysosomal membrane; ISO:MGI.
DR GO; GO:0005764; C:lysosome; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:MGI.
DR GO; GO:0042803; F:protein homodimerization activity; ISO:MGI.
DR InterPro; IPR029399; TMEM192.
DR PANTHER; PTHR31592; PTHR31592; 1.
DR Pfam; PF14802; TMEM192; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Endosome; Lysosome; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..266
FT /note="Transmembrane protein 192"
FT /id="PRO_0000311268"
FT TOPO_DOM 1..46
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..67
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..89
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..110
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 111..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..171
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 193..266
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 17
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19144319"
FT MOD_RES 213
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q8IY95"
FT MOD_RES 229
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IY95"
FT MOD_RES 230
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IY95"
FT VAR_SEQ 147..191
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_029503"
FT CONFLICT 111
FT /note="E -> K (in Ref. 1; BAE40111)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 266 AA; 30336 MW; CC4E57E034063285 CRC64;
MAAAGRLEDS SLDILQSMDD DPLLDTQPLP HHSLQAQFRP RFHPLPTVII ANLLLLIHVV
FVVLAFLTGV PCLYPNPTED KCPENYTSPL KVQTAIILGK LILWILHLLF ERYVQYHHRK
VRSRGYSQIY RSTRHLKTLA LTIHSSGNTA LLLLLCVQHS FPEPSKLYLE LILAVLALEL
ICSLSCLILY IVKIRRFNRA KPLPDVLEEE KIYAYPSNTA SETGFRTVSS LEEIVEKQED
IIVYLKRHNA LLSKRLLELA TQPART
