ID   TM192_PONAB             Reviewed;         271 AA.
AC   Q5RCG1;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 2.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Transmembrane protein 192;
GN   Name=TMEM192;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q8IY95};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8IY95}. Late
CC       endosome {ECO:0000250|UniProtKB:Q8IY95}.
CC   -!- SIMILARITY: Belongs to the TMEM192 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAH90546.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; CR858309; CAH90546.1; ALT_FRAME; mRNA.
DR   RefSeq; NP_001125290.1; NM_001131818.1.
DR   AlphaFoldDB; Q5RCG1; -.
DR   SMR; Q5RCG1; -.
DR   STRING; 9601.ENSPPYP00000016957; -.
DR   GeneID; 100172188; -.
DR   KEGG; pon:100172188; -.
DR   CTD; 201931; -.
DR   eggNOG; ENOG502RYVA; Eukaryota.
DR   InParanoid; Q5RCG1; -.
DR   OrthoDB; 1249559at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR029399; TMEM192.
DR   PANTHER; PTHR31592; PTHR31592; 1.
DR   Pfam; PF14802; TMEM192; 1.
PE   2: Evidence at transcript level;
KW   Endosome; Lysosome; Membrane; Phosphoprotein; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..271
FT                   /note="Transmembrane protein 192"
FT                   /id="PRO_0000311269"
FT   TOPO_DOM        1..46
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        47..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        68..93
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        115..138
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        162..171
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        193..271
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         15
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IY95"
FT   MOD_RES         17
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IY95"
FT   MOD_RES         213
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IY95"
FT   MOD_RES         229
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IY95"
FT   MOD_RES         230
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IY95"
FT   MOD_RES         269
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IY95"
SQ   SEQUENCE   271 AA;  30964 MW;  07305BD3D757DEC3 CRC64;
     MAAGGRMEDG SLDITQSIED DPLLDAQLLP HHSLQAHFRP RFHPLPTVII VNLLWFIHLV
     FVILAFLTGV LCSYPNPNED KCPGNYTNPL KVQTVIILGK VILWILHLLL ECYIQYHHSK
     IRNRGYNLIY RSTRHLKRLA LMIRSSGNTV LLLILCMQHS FPEPGRLYLD LILAILALEL
     ICSLICLLIY TVKIRRFNKA KPEPDILEEE KIYAYPSNIT SETGFRTISS LEEIVEKQGD
     TIEYLKRHNA LLSKRLLALT SSDLGCQPSR T