ID   TM192_RAT               Reviewed;         266 AA.
AC   Q5U1Y0;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Transmembrane protein 192;
GN   Name=Tmem192;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q8IY95};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8IY95}. Late
CC       endosome {ECO:0000250|UniProtKB:Q8IY95}.
CC   -!- SIMILARITY: Belongs to the TMEM192 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC086402; AAH86402.1; -; mRNA.
DR   RefSeq; NP_001014163.1; NM_001014141.1.
DR   AlphaFoldDB; Q5U1Y0; -.
DR   SMR; Q5U1Y0; -.
DR   iPTMnet; Q5U1Y0; -.
DR   PhosphoSitePlus; Q5U1Y0; -.
DR   PaxDb; Q5U1Y0; -.
DR   Ensembl; ENSRNOT00000104426; ENSRNOP00000084423; ENSRNOG00000030199.
DR   GeneID; 361137; -.
DR   KEGG; rno:361137; -.
DR   UCSC; RGD:1309341; rat.
DR   CTD; 201931; -.
DR   RGD; 1309341; Tmem192.
DR   eggNOG; ENOG502QWR8; Eukaryota.
DR   GeneTree; ENSGT00390000013749; -.
DR   InParanoid; Q5U1Y0; -.
DR   OrthoDB; 1249559at2759; -.
DR   PhylomeDB; Q5U1Y0; -.
DR   PRO; PR:Q5U1Y0; -.
DR   Proteomes; UP000002494; Chromosome 16.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005770; C:late endosome; ISO:RGD.
DR   GO; GO:0005765; C:lysosomal membrane; ISO:RGD.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:RGD.
DR   GO; GO:0042803; F:protein homodimerization activity; ISO:RGD.
DR   InterPro; IPR029399; TMEM192.
DR   PANTHER; PTHR31592; PTHR31592; 1.
DR   Pfam; PF14802; TMEM192; 1.
PE   2: Evidence at transcript level;
KW   Endosome; Lysosome; Membrane; Phosphoprotein; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..266
FT                   /note="Transmembrane protein 192"
FT                   /id="PRO_0000311270"
FT   TOPO_DOM        1..52
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        74..89
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        90..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        111..137
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        159..168
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        169..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        190..266
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         17
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IY95"
FT   MOD_RES         213
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IY95"
FT   MOD_RES         229
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IY95"
FT   MOD_RES         230
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IY95"
SQ   SEQUENCE   266 AA;  30252 MW;  DDE4334B2EA38646 CRC64;
     MAAGGRLEDG SLDILQSTDD DPLLDTQPLP HHSLHAHFRP RFHPLPTVII ANLLLLIHVV
     FVTLAFLTGV LCLYPDPNED KCPENYTNPL KVQTAIILGK VILWILHLLF ERYIQYHHRK
     VRSRGYSQIY RSTRHLKALA LTIHSSGNTA LLLLLCVQYS FPEPNKLYLE LILAVLALEL
     ICSLSCLVLY TVKIRRFNKA KPQPDVLEEE KCYAYPSNIA SETGFRTVSS LEEIVEKQGD
     IIVYLKRHNA LLSKRLLELA TQPART