ID   TM192_XENLA             Reviewed;         261 AA.
AC   Q66KF2; Q4V822;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 2.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=Transmembrane protein 192;
GN   Name=tmem192;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney, and Spleen;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q8IY95};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8IY95}. Late
CC       endosome {ECO:0000250|UniProtKB:Q8IY95}.
CC   -!- SIMILARITY: Belongs to the TMEM192 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH80426.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC080426; AAH80426.1; ALT_INIT; mRNA.
DR   EMBL; BC097598; AAH97598.1; -; mRNA.
DR   RefSeq; NP_001086471.1; NM_001093002.1.
DR   AlphaFoldDB; Q66KF2; -.
DR   SMR; Q66KF2; -.
DR   DNASU; 446304; -.
DR   GeneID; 446304; -.
DR   KEGG; xla:446304; -.
DR   CTD; 446304; -.
DR   Xenbase; XB-GENE-5752008; tmem192.L.
DR   OrthoDB; 1249559at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 446304; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR029399; TMEM192.
DR   PANTHER; PTHR31592; PTHR31592; 1.
DR   Pfam; PF14802; TMEM192; 1.
PE   2: Evidence at transcript level;
KW   Endosome; Lysosome; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..261
FT                   /note="Transmembrane protein 192"
FT                   /id="PRO_0000311272"
FT   TRANSMEM        51..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        157..158
FT                   /note="SI -> FF (in Ref. 1; AAH97598)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        179
FT                   /note="L -> V (in Ref. 1; AAH97598)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   261 AA;  29631 MW;  2F155B2932917303 CRC64;
     MERNSRIDSS GDLTQSADED CFLDAPLLPS QKLQSVIRPH FHPVPTVCIS ILLALINLAY
     VTLAVVAFYF CLFSGKKKEC NQSVAPFNLS TVLVISKLIL WLLHVVNERF AHHHHCKAKN
     KGFLHLYRST RHLKGLPLII HSTGNAALLL ILSVQDSISS NRQLYPCLIL SVLLLELILS
     VICLIIYTVR IYRFNKRKPR PDIIEEEKIN AYEGHVNPEI GFRHRASLEE VVEKQGDTIE
     YLKHHNALLS KQLLALTSNQ D