ID   TM192_XENTR             Reviewed;         263 AA.
AC   Q5EAL6;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Transmembrane protein 192;
GN   Name=tmem192; ORFNames=TEgg136c01.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q8IY95};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8IY95}. Late
CC       endosome {ECO:0000250|UniProtKB:Q8IY95}.
CC   -!- SIMILARITY: Belongs to the TMEM192 family. {ECO:0000305}.
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DR   EMBL; CR761262; CAJ81273.1; -; mRNA.
DR   EMBL; BC090374; AAH90374.1; -; mRNA.
DR   RefSeq; NP_001016373.1; NM_001016373.2.
DR   AlphaFoldDB; Q5EAL6; -.
DR   SMR; Q5EAL6; -.
DR   STRING; 8364.ENSXETP00000059816; -.
DR   PaxDb; Q5EAL6; -.
DR   GeneID; 549127; -.
DR   KEGG; xtr:549127; -.
DR   CTD; 201931; -.
DR   Xenbase; XB-GENE-5751968; tmem192.
DR   eggNOG; ENOG502RYVA; Eukaryota.
DR   HOGENOM; CLU_086771_0_0_1; -.
DR   InParanoid; Q5EAL6; -.
DR   OrthoDB; 1249559at2759; -.
DR   PhylomeDB; Q5EAL6; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000017061; Expressed in egg cell and 12 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005770; C:late endosome; IBA:GO_Central.
DR   GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR   InterPro; IPR029399; TMEM192.
DR   PANTHER; PTHR31592; PTHR31592; 1.
DR   Pfam; PF14802; TMEM192; 1.
PE   2: Evidence at transcript level;
KW   Endosome; Lysosome; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..263
FT                   /note="Transmembrane protein 192"
FT                   /id="PRO_0000311273"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        137..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        169..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   263 AA;  29462 MW;  28D4B50ED3D53682 CRC64;
     MAALSTGLST SSGDLTQSAD EDGFLDAPLL PSQKLQSVIR PHFHPVPTIC ISILLALVNL
     AYVTLAVVAI YFCLFSEKEK KCKQSIDPFQ LSTVLVISKL VLWLLHVVNE RFAQHHHCKA
     RSRGFLHLYR STRHLKALPL IIHSTGNAAL LLILSVQDSF TSNSQLYPCL ILSVLLLELI
     LSVICLIIYT VRIYRFNKSK PRPDIIEEEK INAFHGHVNP EIGFRHSASL EEVVEKQGDT
     IEYLKHHNAL LSKQLLALAS NQD