ID   TM198_BOVIN             Reviewed;         360 AA.
AC   Q08E36;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Transmembrane protein 198;
GN   Name=TMEM198;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Promotes LRP6 phosphorylation by casein kinases and thereby
CC       plays a role in Wnt signaling. May be a membrane scaffold protein
CC       involved in the self-aggregation of LRP6 to further enhance its
CC       activity (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with LRP6. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}. Cell membrane {ECO:0000250}. Cytoplasmic vesicle
CC       {ECO:0000250}. Note=Largely located to vesicle-like structures.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TMEM198 family. {ECO:0000305}.
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DR   EMBL; BC123441; AAI23442.1; -; mRNA.
DR   RefSeq; NP_001071578.1; NM_001078110.1.
DR   RefSeq; XP_005202928.1; XM_005202871.3.
DR   AlphaFoldDB; Q08E36; -.
DR   STRING; 9913.ENSBTAP00000027368; -.
DR   PaxDb; Q08E36; -.
DR   PRIDE; Q08E36; -.
DR   Ensembl; ENSBTAT00000027368; ENSBTAP00000027368; ENSBTAG00000020540.
DR   GeneID; 768235; -.
DR   KEGG; bta:768235; -.
DR   CTD; 130612; -.
DR   VEuPathDB; HostDB:ENSBTAG00000020540; -.
DR   VGNC; VGNC:36019; TMEM198.
DR   eggNOG; ENOG502QS1E; Eukaryota.
DR   GeneTree; ENSGT00390000016940; -.
DR   HOGENOM; CLU_043600_0_0_1; -.
DR   InParanoid; Q08E36; -.
DR   OMA; CWLTWVV; -.
DR   OrthoDB; 1509246at2759; -.
DR   TreeFam; TF323324; -.
DR   Proteomes; UP000009136; Chromosome 2.
DR   Bgee; ENSBTAG00000020540; Expressed in adenohypophysis and 82 other tissues.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IBA:GO_Central.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR025256; DUF4203.
DR   InterPro; IPR040236; TMEM198.
DR   PANTHER; PTHR31247; PTHR31247; 1.
DR   Pfam; PF13886; DUF4203; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasmic vesicle; Developmental protein; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix;
KW   Wnt signaling pathway.
FT   CHAIN           1..360
FT                   /note="Transmembrane protein 198"
FT                   /id="PRO_0000326029"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        59..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        116..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        145..165
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        177..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          261..304
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          324..360
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        282..299
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   360 AA;  39609 MW;  2E7A5616A9CE41B8 CRC64;
     MPGTVATLRF QLLPPEPDDA FWGAPCEQPL ERRYEALPAL VCIMCCLFGV VYCFFGYRCF
     KAVLFLTGLL FGSVVIFLLC YRERVLETQL SAGASAGIAL GIGLLCGLVA MLVRSVGLFL
     VGLLLGLLLA AAALLGSAPY YQPGSVWGPL GLLLGGGLLC ALLTLRWPRP LTTLATAVTG
     AALIATAADY FAELLLLARY AVERLRAAPV PPLCWRSWAL LALWPLLSLM GVLVQWRVTT
     ERDSHTEVVI SRQRRRVQLM RIRQQEERKE KRRKKRPPRA LPRGSRAPPR PGPPDPAYRR
     RPVPIKRFNG DILSPSYIQS FRDRQTGSSL SSFMASPTDA DYEYGSRGPL TACSGPPVRV