TM198_HUMAN
ID TM198_HUMAN Reviewed; 360 AA.
AC Q66K66;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Transmembrane protein 198;
GN Name=TMEM198;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, AND INTERACTION WITH LRP6.
RX PubMed=21536646; DOI=10.1128/mcb.05103-11;
RA Liang J., Fu Y., Cruciat C.M., Jia S., Wang Y., Tong Z., Tao Q.,
RA Ingelfinger D., Boutros M., Meng A., Niehrs C., Wu W.;
RT "Transmembrane protein 198 promotes LRP6 phosphorylation and Wnt signaling
RT activation.";
RL Mol. Cell. Biol. 31:2577-2590(2011).
CC -!- FUNCTION: Promotes LRP6 phosphorylation by casein kinases and thereby
CC plays a role in Wnt signaling. May be a membrane scaffold protein
CC involved in the self-aggregation of LRP6 to further enhance its
CC activity. {ECO:0000269|PubMed:21536646}.
CC -!- SUBUNIT: Interacts with LRP6. {ECO:0000269|PubMed:21536646}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}. Cell membrane {ECO:0000250}. Cytoplasmic vesicle
CC {ECO:0000250}. Note=Largely located to vesicle-like structures.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TMEM198 family. {ECO:0000305}.
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DR EMBL; CH471063; EAW70771.1; -; Genomic_DNA.
DR EMBL; BC080573; AAH80573.1; -; mRNA.
DR CCDS; CCDS33385.1; -.
DR RefSeq; NP_001005209.1; NM_001005209.2.
DR RefSeq; NP_001290027.1; NM_001303098.1.
DR RefSeq; XP_016858856.1; XM_017003367.1.
DR AlphaFoldDB; Q66K66; -.
DR STRING; 9606.ENSP00000343507; -.
DR iPTMnet; Q66K66; -.
DR PhosphoSitePlus; Q66K66; -.
DR BioMuta; TMEM198; -.
DR DMDM; 74736317; -.
DR jPOST; Q66K66; -.
DR MassIVE; Q66K66; -.
DR PaxDb; Q66K66; -.
DR PeptideAtlas; Q66K66; -.
DR PRIDE; Q66K66; -.
DR ProteomicsDB; 65956; -.
DR Antibodypedia; 56764; 8 antibodies from 4 providers.
DR DNASU; 130612; -.
DR Ensembl; ENST00000344458.6; ENSP00000343507.2; ENSG00000188760.11.
DR Ensembl; ENST00000373883.4; ENSP00000362990.3; ENSG00000188760.11.
DR GeneID; 130612; -.
DR KEGG; hsa:130612; -.
DR MANE-Select; ENST00000373883.4; ENSP00000362990.3; NM_001005209.3; NP_001005209.1.
DR UCSC; uc002vme.5; human.
DR CTD; 130612; -.
DR GeneCards; TMEM198; -.
DR HGNC; HGNC:33704; TMEM198.
DR HPA; ENSG00000188760; Tissue enhanced (brain).
DR neXtProt; NX_Q66K66; -.
DR OpenTargets; ENSG00000188760; -.
DR PharmGKB; PA162406347; -.
DR VEuPathDB; HostDB:ENSG00000188760; -.
DR eggNOG; ENOG502QS1E; Eukaryota.
DR GeneTree; ENSGT00390000016940; -.
DR InParanoid; Q66K66; -.
DR OMA; CWLTWVV; -.
DR OrthoDB; 1509246at2759; -.
DR PhylomeDB; Q66K66; -.
DR TreeFam; TF323324; -.
DR PathwayCommons; Q66K66; -.
DR SignaLink; Q66K66; -.
DR BioGRID-ORCS; 130612; 8 hits in 1080 CRISPR screens.
DR ChiTaRS; TMEM198; human.
DR GenomeRNAi; 130612; -.
DR Pharos; Q66K66; Tdark.
DR PRO; PR:Q66K66; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q66K66; protein.
DR Bgee; ENSG00000188760; Expressed in prefrontal cortex and 110 other tissues.
DR ExpressionAtlas; Q66K66; baseline and differential.
DR Genevisible; Q66K66; HS.
DR GO; GO:0031410; C:cytoplasmic vesicle; IDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IDA:UniProtKB.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR025256; DUF4203.
DR InterPro; IPR040236; TMEM198.
DR PANTHER; PTHR31247; PTHR31247; 1.
DR Pfam; PF13886; DUF4203; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Cytoplasmic vesicle; Developmental protein; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix;
KW Wnt signaling pathway.
FT CHAIN 1..360
FT /note="Transmembrane protein 198"
FT /id="PRO_0000326030"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..79
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 218..238
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 260..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 324..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 282..299
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 360 AA; 39475 MW; 19094DCD0EE8AEEF CRC64;
MPGTVATLRF QLLPPEPDDA FWGAPCEQPL ERRYQALPAL VCIMCCLFGV VYCFFGYRCF
KAVLFLTGLL FGSVVIFLLC YRERVLETQL SAGASAGIAL GIGLLCGLVA MLVRSVGLFL
VGLLLGLLLA AAALLGSAPY YQPGSVWGPL GLLLGGGLLC ALLTLRWPRP LTTLATAVTG
AALIATAADY FAELLLLGRY VVERLRAAPV PPLCWRSWAL LALWPLLSLM GVLVQWRVTA
EGDSHTEVVI SRQRRRVQLM RIRQQEDRKE KRRKKRPPRA PLRGPRAPPR PGPPDPAYRR
RPVPIKRFNG DVLSPSYIQS FRDRQTGSSL SSFMASPTDA DYEYGSRGPL TACSGPPVRV
