ID   TM1L2_XENLA             Reviewed;         507 AA.
AC   Q68FJ8;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=TOM1-like protein 2;
DE   AltName: Full=Target of Myb-like protein 2;
GN   Name=tom1l2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable role in protein transport. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with clathrin. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TOM1 family. {ECO:0000305}.
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DR   EMBL; BC079756; AAH79756.1; -; mRNA.
DR   RefSeq; NP_001087418.1; NM_001093949.1.
DR   AlphaFoldDB; Q68FJ8; -.
DR   SMR; Q68FJ8; -.
DR   MaxQB; Q68FJ8; -.
DR   DNASU; 447242; -.
DR   GeneID; 447242; -.
DR   KEGG; xla:447242; -.
DR   CTD; 447242; -.
DR   Xenbase; XB-GENE-1012170; tom1l2.L.
DR   OrthoDB; 1213216at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 447242; Expressed in brain and 19 other tissues.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR   GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.58.160; -; 1.
DR   Gene3D; 1.25.40.90; -; 1.
DR   InterPro; IPR008942; ENTH_VHS.
DR   InterPro; IPR004152; GAT_dom.
DR   InterPro; IPR038425; GAT_sf.
DR   InterPro; IPR014645; TOM1.
DR   InterPro; IPR027429; TOM1L2.
DR   InterPro; IPR002014; VHS_dom.
DR   PANTHER; PTHR13856:SF31; PTHR13856:SF31; 1.
DR   Pfam; PF03127; GAT; 1.
DR   Pfam; PF00790; VHS; 1.
DR   PIRSF; PIRSF036948; TOM1; 1.
DR   SMART; SM00288; VHS; 1.
DR   SUPFAM; SSF48464; SSF48464; 1.
DR   PROSITE; PS50909; GAT; 1.
DR   PROSITE; PS50179; VHS; 1.
PE   2: Evidence at transcript level;
KW   Protein transport; Reference proteome; Transport.
FT   CHAIN           1..507
FT                   /note="TOM1-like protein 2"
FT                   /id="PRO_0000278792"
FT   DOMAIN          20..152
FT                   /note="VHS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00218"
FT   DOMAIN          221..309
FT                   /note="GAT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00373"
FT   REGION          164..219
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          466..507
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           330..335
FT                   /note="Clathrin-binding"
FT   COMPBIAS        170..202
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   507 AA;  55853 MW;  2E0C7D3CA26969A1 CRC64;
     MEFLLGNPYS TPVGQCIEKA TDGSLQSEDW TLNMEICDII NETEEGPKDA MRALKKRLNG
     NRNYREVMLA LTVLETCVKN CGHRFHVQVT HRDFIDGILV KIISPKNNPP TIVQDKVLAL
     IQAWADAFRS SPDLTGVVHI YEELKRKGIE FPMADLDALS PIHTPQRSVP EVDPATNMHT
     SQTQKRDSFS NLSNSKSTST PYTAPGGPPP NVGGPISANS EQIGRLRSEL DIVRGNVKVM
     SEMLTEMTPG QEGASDLELL QDLNRTCRTM QERIVELISR VSNEEVTEEL LHVNDDLNNV
     FLRYERFERY RLGRSAQNTN GVLSDVTEDN LIDLGPGSPA VVSPMLANTA PSNLSSQLGG
     LDVGTNSVSS TLSALPTTNP KDDFDMFAHT RTNSLADQRK NVTYEDPQAL GGLVSALDVR
     KQNIGGIPVS QPSDMDDIED WLSKDLKGDE LEEGVTSEEF DKFLEERAKA AERVPDLPSP
     PTGEPAQPMN PAGRKKQESS EDKLFAL