ID   TM202_HUMAN             Reviewed;         273 AA.
AC   A6NGA9;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Transmembrane protein 202;
GN   Name=TMEM202;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA   Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA   Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA   Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA   O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA   Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA   Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human chromosome
RT   15.";
RL   Nature 440:671-675(2006).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; AC079322; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS32287.1; -.
DR   RefSeq; NP_001073931.1; NM_001080462.1.
DR   AlphaFoldDB; A6NGA9; -.
DR   STRING; 9606.ENSP00000340212; -.
DR   TCDB; 8.A.16.3.2; the ca(+) channel auxiliary subunit Gama1-Gama8 (ccaGama) family.
DR   iPTMnet; A6NGA9; -.
DR   PhosphoSitePlus; A6NGA9; -.
DR   BioMuta; TMEM202; -.
DR   PaxDb; A6NGA9; -.
DR   PeptideAtlas; A6NGA9; -.
DR   PRIDE; A6NGA9; -.
DR   Antibodypedia; 66347; 12 antibodies from 7 providers.
DR   DNASU; 338949; -.
DR   Ensembl; ENST00000341689.4; ENSP00000340212.3; ENSG00000187806.9.
DR   GeneID; 338949; -.
DR   KEGG; hsa:338949; -.
DR   MANE-Select; ENST00000341689.4; ENSP00000340212.3; NM_001080462.3; NP_001073931.1.
DR   UCSC; uc002auq.4; human.
DR   CTD; 338949; -.
DR   GeneCards; TMEM202; -.
DR   HGNC; HGNC:33733; TMEM202.
DR   HPA; ENSG00000187806; Tissue enriched (testis).
DR   neXtProt; NX_A6NGA9; -.
DR   PharmGKB; PA162406376; -.
DR   VEuPathDB; HostDB:ENSG00000187806; -.
DR   eggNOG; ENOG502R1C0; Eukaryota.
DR   GeneTree; ENSGT01050000244814; -.
DR   HOGENOM; CLU_093889_0_0_1; -.
DR   InParanoid; A6NGA9; -.
DR   OMA; HELCWNH; -.
DR   OrthoDB; 1332350at2759; -.
DR   PhylomeDB; A6NGA9; -.
DR   TreeFam; TF337324; -.
DR   PathwayCommons; A6NGA9; -.
DR   SignaLink; A6NGA9; -.
DR   BioGRID-ORCS; 338949; 19 hits in 1065 CRISPR screens.
DR   GenomeRNAi; 338949; -.
DR   Pharos; A6NGA9; Tdark.
DR   PRO; PR:A6NGA9; -.
DR   Proteomes; UP000005640; Chromosome 15.
DR   RNAct; A6NGA9; protein.
DR   Bgee; ENSG00000187806; Expressed in left testis and 17 other tissues.
DR   ExpressionAtlas; A6NGA9; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
PE   4: Predicted;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..273
FT                   /note="Transmembrane protein 202"
FT                   /id="PRO_0000317201"
FT   TRANSMEM        53..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        121..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        155..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        189..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          242..273
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         204
FT                   /note="M -> L (in dbSNP:rs16956904)"
FT                   /id="VAR_051434"
SQ   SEQUENCE   273 AA;  31353 MW;  7912F1A665B28424 CRC64;
     MERREHLTLT FHSPEVPKIK GNRKYQRPTV PAKKHPSASM SCQRQQQLMD QAHIYIRTLC
     GSLCSFSLLM LIAMSPLNWV QFLVIKNGLE LYAGLWTLCN HELCWSHTPK PPYYLQYSRA
     FFLISVFTIL TGLGWLFSSW ILNRGSMTTN LDLKVSMLSF ISATCLLLCL NLFVAQVHWH
     TRDAMESDLL WTYYLNWCSD IFYMFAGIIS LLNYLTSRSP ACDENVTVIP TERSRLGVGP
     VTTVSPAKDE GPRSEMESLS VREKNLPKSG LWW