TM203_HUMAN
ID TM203_HUMAN Reviewed; 136 AA.
AC Q969S6; Q6NW08;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Transmembrane protein 203;
GN Name=TMEM203;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, Lung, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH ATP2A2; ITPR3 AND
RP STIM1.
RX PubMed=25996873; DOI=10.1371/journal.pone.0127480;
RA Shambharkar P.B., Bittinger M., Latario B., Xiong Z., Bandyopadhyay S.,
RA Davis V., Lin V., Yang Y., Valdez R., Labow M.A.;
RT "TMEM203 is a novel regulator of intracellular calcium homeostasis and is
RT required for spermatogenesis.";
RL PLoS ONE 10:E0127480-E0127480(2015).
CC -!- FUNCTION: Involved in the regulation of cellular calcium homeotasis
CC (PubMed:25996873). Required for spermatogenesis (PubMed:25996873).
CC {ECO:0000269|PubMed:25996873}.
CC -!- SUBUNIT: Interacts with ATP2A2, ITPR3 and STIM1.
CC {ECO:0000269|PubMed:25996873}.
CC -!- INTERACTION:
CC Q969S6; P16157-17: ANK1; NbExp=3; IntAct=EBI-12274070, EBI-941819;
CC Q969S6; Q13520: AQP6; NbExp=3; IntAct=EBI-12274070, EBI-13059134;
CC Q969S6; O75787: ATP6AP2; NbExp=3; IntAct=EBI-12274070, EBI-2512037;
CC Q969S6; P09693: CD3G; NbExp=3; IntAct=EBI-12274070, EBI-3862428;
CC Q969S6; P34972: CNR2; NbExp=3; IntAct=EBI-12274070, EBI-2835940;
CC Q969S6; Q7Z7G2: CPLX4; NbExp=3; IntAct=EBI-12274070, EBI-18013275;
CC Q969S6; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-12274070, EBI-6942903;
CC Q969S6; Q15125: EBP; NbExp=3; IntAct=EBI-12274070, EBI-3915253;
CC Q969S6; Q9GZR5: ELOVL4; NbExp=3; IntAct=EBI-12274070, EBI-18535450;
CC Q969S6; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-12274070, EBI-781551;
CC Q969S6; Q8TBP5: FAM174A; NbExp=3; IntAct=EBI-12274070, EBI-18636064;
CC Q969S6; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-12274070, EBI-18304435;
CC Q969S6; O15552: FFAR2; NbExp=3; IntAct=EBI-12274070, EBI-2833872;
CC Q969S6; Q8NBQ5: HSD17B11; NbExp=3; IntAct=EBI-12274070, EBI-1052304;
CC Q969S6; Q7Z5P4: HSD17B13; NbExp=3; IntAct=EBI-12274070, EBI-18053395;
CC Q969S6; P48051: KCNJ6; NbExp=3; IntAct=EBI-12274070, EBI-12017638;
CC Q969S6; O95867: LY6G6C; NbExp=3; IntAct=EBI-12274070, EBI-9088345;
CC Q969S6; Q9NQG1: MANBAL; NbExp=3; IntAct=EBI-12274070, EBI-3867271;
CC Q969S6; Q6N075: MFSD5; NbExp=3; IntAct=EBI-12274070, EBI-3920969;
CC Q969S6; Q15546: MMD; NbExp=3; IntAct=EBI-12274070, EBI-17873222;
CC Q969S6; Q13113: PDZK1IP1; NbExp=3; IntAct=EBI-12274070, EBI-716063;
CC Q969S6; Q86VR2: RETREG3; NbExp=3; IntAct=EBI-12274070, EBI-10192441;
CC Q969S6; Q96TC7: RMDN3; NbExp=3; IntAct=EBI-12274070, EBI-1056589;
CC Q969S6; Q6P5S7: RNASEK; NbExp=3; IntAct=EBI-12274070, EBI-18397230;
CC Q969S6; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-12274070, EBI-18159983;
CC Q969S6; P54219-3: SLC18A1; NbExp=3; IntAct=EBI-12274070, EBI-17595455;
CC Q969S6; Q8WWF3: SSMEM1; NbExp=3; IntAct=EBI-12274070, EBI-17280858;
CC Q969S6; P27105: STOM; NbExp=3; IntAct=EBI-12274070, EBI-1211440;
CC Q969S6; Q12846: STX4; NbExp=3; IntAct=EBI-12274070, EBI-744942;
CC Q969S6; Q9NPL8: TIMMDC1; NbExp=3; IntAct=EBI-12274070, EBI-6268651;
CC Q969S6; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-12274070, EBI-8638294;
CC Q969S6; Q8WY98: TMEM234; NbExp=3; IntAct=EBI-12274070, EBI-8642211;
CC Q969S6; Q4KMG9: TMEM52B; NbExp=3; IntAct=EBI-12274070, EBI-18178701;
CC Q969S6; Q9H2L4: TMEM60; NbExp=3; IntAct=EBI-12274070, EBI-2852148;
CC Q969S6; Q8N661: TMEM86B; NbExp=3; IntAct=EBI-12274070, EBI-2548832;
CC Q969S6; Q9Y320: TMX2; NbExp=3; IntAct=EBI-12274070, EBI-6447886;
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:25996873}; Multi-pass membrane protein
CC {ECO:0000305}.
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DR EMBL; CH471090; EAW88365.1; -; Genomic_DNA.
DR EMBL; BC009283; AAH09283.1; -; mRNA.
DR EMBL; BC009461; AAH09461.1; -; mRNA.
DR EMBL; BC067786; AAH67786.1; -; mRNA.
DR CCDS; CCDS35185.1; -.
DR RefSeq; NP_444273.1; NM_053045.1.
DR AlphaFoldDB; Q969S6; -.
DR BioGRID; 125117; 41.
DR IntAct; Q969S6; 37.
DR STRING; 9606.ENSP00000375053; -.
DR TCDB; 8.A.76.1.1; the tmem203 or pf14967 (tmem203) family.
DR BioMuta; TMEM203; -.
DR DMDM; 74731059; -.
DR PaxDb; Q969S6; -.
DR PRIDE; Q969S6; -.
DR ProteomicsDB; 75832; -.
DR Antibodypedia; 64518; 2 antibodies from 2 providers.
DR DNASU; 94107; -.
DR Ensembl; ENST00000343666.6; ENSP00000375053.4; ENSG00000187713.7.
DR GeneID; 94107; -.
DR KEGG; hsa:94107; -.
DR MANE-Select; ENST00000343666.6; ENSP00000375053.4; NM_053045.2; NP_444273.1.
DR UCSC; uc004clv.4; human.
DR CTD; 94107; -.
DR DisGeNET; 94107; -.
DR GeneCards; TMEM203; -.
DR HGNC; HGNC:28217; TMEM203.
DR HPA; ENSG00000187713; Low tissue specificity.
DR MIM; 616499; gene.
DR neXtProt; NX_Q969S6; -.
DR OpenTargets; ENSG00000187713; -.
DR PharmGKB; PA162406377; -.
DR VEuPathDB; HostDB:ENSG00000187713; -.
DR eggNOG; KOG3631; Eukaryota.
DR GeneTree; ENSGT00510000049510; -.
DR HOGENOM; CLU_145619_1_0_1; -.
DR InParanoid; Q969S6; -.
DR OMA; FEIWINL; -.
DR OrthoDB; 1407976at2759; -.
DR PhylomeDB; Q969S6; -.
DR TreeFam; TF323514; -.
DR PathwayCommons; Q969S6; -.
DR SignaLink; Q969S6; -.
DR BioGRID-ORCS; 94107; 18 hits in 1082 CRISPR screens.
DR GenomeRNAi; 94107; -.
DR Pharos; Q969S6; Tdark.
DR PRO; PR:Q969S6; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q969S6; protein.
DR Bgee; ENSG00000187713; Expressed in apex of heart and 96 other tissues.
DR Genevisible; Q969S6; HS.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0006874; P:cellular calcium ion homeostasis; IDA:UniProtKB.
DR GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
DR InterPro; IPR019396; TM_Fragile-X-F-assoc.
DR PANTHER; PTHR13568; PTHR13568; 1.
PE 1: Evidence at protein level;
KW Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..136
FT /note="Transmembrane protein 203"
FT /id="PRO_0000317203"
FT TRANSMEM 14..34
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..72
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 96
FT /note="V -> F (in Ref. 2; AAH67786)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 136 AA; 15760 MW; 87CA7D87F00B16FC CRC64;
MLFSLRELVQ WLGFATFEIF VHLLALLVFS VLLALRVDGL VPGLSWWNVF VPFFAADGLS
TYFTTIVSVR LFQDGEKRLA VLRLFWVLTV LSLKFVFEML LCQKLAEQTR ELWFGLITSP
LFILLQLLMI RACRVN
