ID   TM203_XENLA             Reviewed;         136 AA.
AC   Q6GNX5;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=Transmembrane protein 203;
GN   Name=tmem203;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the regulation of cellular calcium homeotasis.
CC       {ECO:0000250|UniProtKB:Q969S6}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q969S6}; Multi-pass membrane protein
CC       {ECO:0000305}.
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DR   EMBL; BC073376; AAH73376.1; -; mRNA.
DR   RefSeq; NP_001085810.1; NM_001092341.1.
DR   RefSeq; XP_018087480.1; XM_018231991.1.
DR   RefSeq; XP_018087481.1; XM_018231992.1.
DR   AlphaFoldDB; Q6GNX5; -.
DR   DNASU; 444237; -.
DR   GeneID; 444237; -.
DR   KEGG; xla:444237; -.
DR   CTD; 444237; -.
DR   Xenbase; XB-GENE-6255697; tmem203.S.
DR   OMA; FEIWINL; -.
DR   OrthoDB; 1407976at2759; -.
DR   Proteomes; UP000186698; Chromosome 8S.
DR   Bgee; 444237; Expressed in oocyte and 19 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR019396; TM_Fragile-X-F-assoc.
DR   PANTHER; PTHR13568; PTHR13568; 1.
DR   Pfam; PF10269; Tmemb_185A; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..136
FT                   /note="Transmembrane protein 203"
FT                   /id="PRO_0000317205"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        50..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        112..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   136 AA;  15885 MW;  8D3679F81D762831 CRC64;
     MLFSLLELVQ WLGFAQLEIF LHISALLVFT VLLALKADGF APSMSWWNVF IPFFTADGLS
     TYFTTIVTVR LFQDGEKRQA VLRLFWILTI LSLKFIFEML LCQKLVEQSR ELWYGLIMSP
     IFILLQLLMI RACRVN