ID   TM203_XENTR             Reviewed;         136 AA.
AC   Q5XH84;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Transmembrane protein 203;
GN   Name=tmem203;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the regulation of cellular calcium homeotasis.
CC       {ECO:0000250|UniProtKB:Q969S6}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q969S6}; Multi-pass membrane protein
CC       {ECO:0000305}.
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DR   EMBL; BC084189; AAH84189.1; -; mRNA.
DR   RefSeq; NP_001011060.1; NM_001011060.1.
DR   AlphaFoldDB; Q5XH84; -.
DR   DNASU; 496470; -.
DR   GeneID; 496470; -.
DR   KEGG; xtr:496470; -.
DR   CTD; 94107; -.
DR   Xenbase; XB-GENE-6454036; tmem203.
DR   InParanoid; Q5XH84; -.
DR   OrthoDB; 1407976at2759; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006874; P:cellular calcium ion homeostasis; IBA:GO_Central.
DR   InterPro; IPR019396; TM_Fragile-X-F-assoc.
DR   PANTHER; PTHR13568; PTHR13568; 1.
DR   Pfam; PF10269; Tmemb_185A; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..136
FT                   /note="Transmembrane protein 203"
FT                   /id="PRO_0000317206"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        50..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        112..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   136 AA;  15982 MW;  6B2252A17E398534 CRC64;
     MLFSLLELVQ WLGFAQLEIF LHIWALLVFT VLLALKADGF APDMSWWNIF IPFFTADGLS
     TYFTTIVTVR LFQDGEKRQA VLRLFWILTI LSLKFVFEML LCQKLVEQSR ELWFGLIMSP
     VFILLQLLMI RACRVN