ID   TM204_BOVIN             Reviewed;         226 AA.
AC   Q0IIE5;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Transmembrane protein 204;
DE   AltName: Full=Claudin-like protein 24;
GN   Name=TMEM204; Synonyms=CLP24;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Brain cortex;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Can influence paracellular permeability. Appears to be
CC       involved in cell-cell interactions through adherens (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell junction, adherens junction. Cell membrane
CC       {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Co-
CC       localizes with the beta-catenin adherins. {ECO:0000250}.
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DR   EMBL; BC122684; AAI22685.1; -; mRNA.
DR   RefSeq; NP_001069845.1; NM_001076377.1.
DR   AlphaFoldDB; Q0IIE5; -.
DR   SMR; Q0IIE5; -.
DR   STRING; 9913.ENSBTAP00000009534; -.
DR   PaxDb; Q0IIE5; -.
DR   Ensembl; ENSBTAT00000009534; ENSBTAP00000009534; ENSBTAG00000007246.
DR   GeneID; 615464; -.
DR   KEGG; bta:615464; -.
DR   CTD; 79652; -.
DR   VEuPathDB; HostDB:ENSBTAG00000007246; -.
DR   VGNC; VGNC:36026; TMEM204.
DR   eggNOG; ENOG502QTQQ; Eukaryota.
DR   GeneTree; ENSGT00390000015528; -.
DR   HOGENOM; CLU_107201_0_0_1; -.
DR   InParanoid; Q0IIE5; -.
DR   OMA; EYVESPC; -.
DR   OrthoDB; 1317636at2759; -.
DR   TreeFam; TF331492; -.
DR   Proteomes; UP000009136; Chromosome 25.
DR   Bgee; ENSBTAG00000007246; Expressed in bone marrow and 104 other tissues.
DR   ExpressionAtlas; Q0IIE5; baseline and differential.
DR   GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001945; P:lymph vessel development; IBA:GO_Central.
DR   GO; GO:0030947; P:regulation of vascular endothelial growth factor receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0051145; P:smooth muscle cell differentiation; IBA:GO_Central.
DR   InterPro; IPR038992; TMEM204.
DR   PANTHER; PTHR14627; PTHR14627; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..226
FT                   /note="Transmembrane protein 204"
FT                   /id="PRO_0000283063"
FT   TOPO_DOM        1..5
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        27..103
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        125..136
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        137..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        158..170
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        171..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        192..226
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   226 AA;  24552 MW;  A1CA0465FE6F5017 CRC64;
     MTVRKVVATA VLVALVSLVL NNAAAFTPNW VYQTLEDGRR RSVGLWWACW LVERPRGAPG
     PGARPGPADV RDCEALGWGS EAAGFQESRG TVKLQFDMMR ACNLVATAAL AAGQLTFVLG
     LTGLPLLSPD AQCWEEAMAA AFQLASFVLV IGLVTFYRIG PYTSLSWSCY LNIGACLLAT
     LAAAMLIWNV LHRREDCTAP RVIVISRSLT ARFRRGLDND YVESPC