TM204_HUMAN
ID TM204_HUMAN Reviewed; 226 AA.
AC Q9BSN7; D3DU76; Q3KRC1; Q9H7G5;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Transmembrane protein 204;
DE AltName: Full=Claudin-like protein 24;
GN Name=TMEM204; Synonyms=C16orf30, CLP24; ORFNames=UNQ6509/PRO21434;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], POSSIBLE FUNCTION, SUBCELLULAR LOCATION, AND
RP TISSUE SPECIFICITY.
RC TISSUE=Endothelial cell;
RX PubMed=15206924; DOI=10.1111/j.1432-1033.2004.04186.x;
RA Kearsey J., Petit S., De Oliveira C., Schweighoffer F.;
RT "A novel four transmembrane spanning protein, CLP24.";
RL Eur. J. Biochem. 271:2584-2592(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Adipose tissue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11157797; DOI=10.1093/hmg/10.4.339;
RA Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C.,
RA Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.;
RT "Sequence, structure and pathology of the fully annotated terminal 2 Mb of
RT the short arm of human chromosome 16.";
RL Hum. Mol. Genet. 10:339-352(2001).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung, and Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Can influence paracellular permeability. Appears to be
CC involved in cell-cell interactions through adherens.
CC -!- SUBCELLULAR LOCATION: Cell junction, adherens junction
CC {ECO:0000269|PubMed:15206924}. Cell membrane
CC {ECO:0000269|PubMed:15206924}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:15206924}. Note=Colocalizes with the beta-catenin
CC adherins.
CC -!- TISSUE SPECIFICITY: Highly expressed in lung, heart, kidney and
CC placenta. Lower expression in thymus, spleen, liver, testis and ovary.
CC Expressed in endothelial and restricted epithelial cell populations.
CC {ECO:0000269|PubMed:15206924}.
CC -!- INDUCTION: By hypoxia.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB14926.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AY676494; AAT78423.1; -; mRNA.
DR EMBL; AY358178; AAQ88545.1; -; mRNA.
DR EMBL; AK024551; BAB14926.1; ALT_FRAME; mRNA.
DR EMBL; AE006467; AAK61286.1; -; Genomic_DNA.
DR EMBL; CH471112; EAW85645.1; -; Genomic_DNA.
DR EMBL; CH471112; EAW85646.1; -; Genomic_DNA.
DR EMBL; BC004932; AAH04932.1; -; mRNA.
DR EMBL; BC105785; AAI05786.1; -; mRNA.
DR CCDS; CCDS42098.1; -.
DR RefSeq; NP_001243470.1; NM_001256541.1.
DR RefSeq; NP_078876.2; NM_024600.5.
DR AlphaFoldDB; Q9BSN7; -.
DR BioGRID; 122780; 12.
DR STRING; 9606.ENSP00000454945; -.
DR TCDB; 8.A.130.1.1; the transmembrane protein 204 (tmem204) family.
DR GlyGen; Q9BSN7; 1 site.
DR iPTMnet; Q9BSN7; -.
DR PhosphoSitePlus; Q9BSN7; -.
DR BioMuta; TMEM204; -.
DR DMDM; 73917798; -.
DR MassIVE; Q9BSN7; -.
DR PaxDb; Q9BSN7; -.
DR PeptideAtlas; Q9BSN7; -.
DR PRIDE; Q9BSN7; -.
DR ProteomicsDB; 78917; -.
DR Antibodypedia; 2862; 84 antibodies from 22 providers.
DR DNASU; 79652; -.
DR Ensembl; ENST00000253934.9; ENSP00000253934.5; ENSG00000131634.14.
DR Ensembl; ENST00000566264.2; ENSP00000454945.1; ENSG00000131634.14.
DR GeneID; 79652; -.
DR KEGG; hsa:79652; -.
DR MANE-Select; ENST00000566264.2; ENSP00000454945.1; NM_024600.6; NP_078876.2.
DR UCSC; uc002cmc.4; human.
DR CTD; 79652; -.
DR DisGeNET; 79652; -.
DR GeneCards; TMEM204; -.
DR HGNC; HGNC:14158; TMEM204.
DR HPA; ENSG00000131634; Low tissue specificity.
DR MIM; 611002; gene.
DR neXtProt; NX_Q9BSN7; -.
DR OpenTargets; ENSG00000131634; -.
DR PharmGKB; PA162406384; -.
DR VEuPathDB; HostDB:ENSG00000131634; -.
DR eggNOG; ENOG502QTQQ; Eukaryota.
DR GeneTree; ENSGT00390000015528; -.
DR HOGENOM; CLU_107201_0_0_1; -.
DR InParanoid; Q9BSN7; -.
DR OMA; EYVESPC; -.
DR OrthoDB; 41516at2759; -.
DR PhylomeDB; Q9BSN7; -.
DR TreeFam; TF331492; -.
DR PathwayCommons; Q9BSN7; -.
DR BioGRID-ORCS; 79652; 17 hits in 1072 CRISPR screens.
DR ChiTaRS; TMEM204; human.
DR GenomeRNAi; 79652; -.
DR Pharos; Q9BSN7; Tdark.
DR PRO; PR:Q9BSN7; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q9BSN7; protein.
DR Bgee; ENSG00000131634; Expressed in right lung and 182 other tissues.
DR Genevisible; Q9BSN7; HS.
DR GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0001945; P:lymph vessel development; IBA:GO_Central.
DR GO; GO:0030947; P:regulation of vascular endothelial growth factor receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0051145; P:smooth muscle cell differentiation; IBA:GO_Central.
DR InterPro; IPR038992; TMEM204.
DR PANTHER; PTHR14627; PTHR14627; 1.
PE 2: Evidence at transcript level;
KW Cell junction; Cell membrane; Glycoprotein; Membrane; Reference proteome;
KW Stress response; Transmembrane; Transmembrane helix.
FT CHAIN 1..226
FT /note="Transmembrane protein 204"
FT /id="PRO_0000089865"
FT TOPO_DOM 1..5
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 27..103
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 125..136
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..170
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 192..226
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 164
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 57
FT /note="G -> A (in dbSNP:rs1057612)"
FT /id="VAR_051435"
SQ SEQUENCE 226 AA; 24540 MW; 2CECA8A5823AE397 CRC64;
MTVQRLVAAA VLVALVSLIL NNVAAFTSNW VCQTLEDGRR RSVGLWRSCW LVDRTRGGPS
PGARAGQVDA HDCEALGWGS EAAGFQESRG TVKLQFDMMR ACNLVATAAL TAGQLTFLLG
LVGLPLLSPD APCWEEAMAA AFQLASFVLV IGLVTFYRIG PYTNLSWSCY LNIGACLLAT
LAAAMLIWNI LHKREDCMAP RVIVISRSLT ARFRRGLDND YVESPC
