ID   TM204_RAT               Reviewed;         226 AA.
AC   Q5M962;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Transmembrane protein 204;
DE   AltName: Full=Claudin-like protein 24;
GN   Name=Tmem204; Synonyms=Clp24;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Can influence paracellular permeability. Appears to be
CC       involved in cell-cell interactions through adherens (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell junction, adherens junction. Cell membrane
CC       {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Co-
CC       localizes with the beta-catenin adherins. {ECO:0000250}.
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DR   EMBL; BC087601; AAH87601.1; -; mRNA.
DR   RefSeq; NP_001009620.1; NM_001009620.1.
DR   RefSeq; XP_017452554.1; XM_017597065.1.
DR   AlphaFoldDB; Q5M962; -.
DR   STRING; 10116.ENSRNOP00000022142; -.
DR   GlyGen; Q5M962; 1 site.
DR   PaxDb; Q5M962; -.
DR   Ensembl; ENSRNOT00000022142; ENSRNOP00000022142; ENSRNOG00000016494.
DR   GeneID; 287129; -.
DR   KEGG; rno:287129; -.
DR   UCSC; RGD:1359314; rat.
DR   CTD; 79652; -.
DR   RGD; 1359314; Tmem204.
DR   eggNOG; ENOG502QTQQ; Eukaryota.
DR   GeneTree; ENSGT00390000015528; -.
DR   HOGENOM; CLU_107201_0_0_1; -.
DR   InParanoid; Q5M962; -.
DR   OMA; EYVESPC; -.
DR   OrthoDB; 1317636at2759; -.
DR   PhylomeDB; Q5M962; -.
DR   TreeFam; TF331492; -.
DR   PRO; PR:Q5M962; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000016494; Expressed in lung and 18 other tissues.
DR   Genevisible; Q5M962; RN.
DR   GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR   GO; GO:0001945; P:lymph vessel development; ISO:RGD.
DR   GO; GO:0030947; P:regulation of vascular endothelial growth factor receptor signaling pathway; ISO:RGD.
DR   GO; GO:0051145; P:smooth muscle cell differentiation; ISO:RGD.
DR   InterPro; IPR038992; TMEM204.
DR   PANTHER; PTHR14627; PTHR14627; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Cell membrane; Glycoprotein; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..226
FT                   /note="Transmembrane protein 204"
FT                   /id="PRO_0000089867"
FT   TOPO_DOM        1..5
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        27..103
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        125..136
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        137..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        158..170
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        171..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        192..226
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        164
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   226 AA;  24701 MW;  24E18378EE501969 CRC64;
     MTVQKLVATA VLVALVSLIL NNAAAFTPNW VYQTLEDGRK RSVGLWKSCW LVDRGKGGTS
     PGTRTGQVDT HDCEVLGWGS ESAGFQESRG TVKLQFDMMR ACNLVATAAL AVGQITFILG
     LTGLPLMSPE SQCWEEAMAA AFQLASFVLV IGLVTFYRIG PYTNLSWSCY LNIGACLLAT
     LAAAMLIWNI LHRREDCMAP RVIVISRSLT ARFRRGLDND YVESPC