TM205_HUMAN
ID TM205_HUMAN Reviewed; 189 AA.
AC Q6UW68;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Transmembrane protein 205;
GN Name=TMEM205; ORFNames=UNQ501/PRO1018;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Small intestine;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pancreas, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=20589834; DOI=10.1002/jcp.22287;
RA Shen D.W., Ma J., Okabe M., Zhang G., Xia D., Gottesman M.M.;
RT "Elevated expression of TMEM205, a hypothetical membrane protein, is
RT associated with cisplatin resistance.";
RL J. Cell. Physiol. 225:822-828(2010).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
CC -!- FUNCTION: In cancer cells, plays a role in resistance to the
CC chemotherapeutic agent cisplatin. {ECO:0000269|PubMed:20589834}.
CC -!- INTERACTION:
CC Q6UW68; Q8N6S5: ARL6IP6; NbExp=3; IntAct=EBI-6269551, EBI-2808844;
CC Q6UW68; Q12983: BNIP3; NbExp=3; IntAct=EBI-6269551, EBI-749464;
CC Q6UW68; P21964: COMT; NbExp=3; IntAct=EBI-6269551, EBI-372265;
CC Q6UW68; O14653: GOSR2; NbExp=3; IntAct=EBI-6269551, EBI-4401517;
CC Q6UW68; P42858: HTT; NbExp=3; IntAct=EBI-6269551, EBI-466029;
CC Q6UW68; O95167: NDUFA3; NbExp=3; IntAct=EBI-6269551, EBI-1246131;
CC Q6UW68; P26678: PLN; NbExp=3; IntAct=EBI-6269551, EBI-692836;
CC Q6UW68; Q0VAQ4: SMAGP; NbExp=3; IntAct=EBI-6269551, EBI-10226799;
CC Q6UW68; O43752: STX6; NbExp=3; IntAct=EBI-6269551, EBI-2695795;
CC Q6UW68; O15400: STX7; NbExp=3; IntAct=EBI-6269551, EBI-3221827;
CC Q6UW68; Q9UNK0: STX8; NbExp=3; IntAct=EBI-6269551, EBI-727240;
CC Q6UW68; P17152: TMEM11; NbExp=3; IntAct=EBI-6269551, EBI-723946;
CC Q6UW68; Q9NV12: TMEM140; NbExp=3; IntAct=EBI-6269551, EBI-2844246;
CC Q6UW68; Q9NSU2-1: TREX1; NbExp=3; IntAct=EBI-6269551, EBI-16746122;
CC Q6UW68; O75379: VAMP4; NbExp=3; IntAct=EBI-6269551, EBI-744953;
CC Q6UW68; Q86Y07: VRK2; NbExp=3; IntAct=EBI-6269551, EBI-1207615;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:20589834}; Multi-
CC pass membrane protein {ECO:0000269|PubMed:20589834}. Note=Located on
CC cell surface microvilli. In cancer cells, transition in subcellular
CC location from cell surface to intracellular regions correlates the
CC progression of cisplatin resistance.
CC -!- TISSUE SPECIFICITY: Widely expressed with highest levels in pancreas,
CC followed by adrenal gland, thyroid, liver, mammary gland, prostate,
CC kidney, and retina; lowest levels in skeletal muscle. Overexpressed in
CC cisplatin-resistant cancer cells (at protein level).
CC {ECO:0000269|PubMed:20589834}.
CC -!- SIMILARITY: Belongs to the TMEM205 family. {ECO:0000305}.
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DR EMBL; AY358949; AAQ89308.1; -; mRNA.
DR EMBL; AK291979; BAF84668.1; -; mRNA.
DR EMBL; CH471106; EAW84191.1; -; Genomic_DNA.
DR EMBL; BC064948; AAH64948.1; -; mRNA.
DR EMBL; BC091472; AAH91472.1; -; mRNA.
DR CCDS; CCDS32909.1; -.
DR RefSeq; NP_001138888.1; NM_001145416.1.
DR RefSeq; NP_001308041.1; NM_001321112.1.
DR RefSeq; NP_001308042.1; NM_001321113.1.
DR RefSeq; NP_001308043.1; NM_001321114.1.
DR RefSeq; NP_212133.1; NM_033408.3.
DR RefSeq; NP_940938.1; NM_198536.2.
DR RefSeq; XP_005259956.1; XM_005259899.2.
DR AlphaFoldDB; Q6UW68; -.
DR BioGRID; 131930; 74.
DR IntAct; Q6UW68; 29.
DR MINT; Q6UW68; -.
DR STRING; 9606.ENSP00000346954; -.
DR TCDB; 9.A.55.1.1; the tmem205 (tmem205) family.
DR iPTMnet; Q6UW68; -.
DR PhosphoSitePlus; Q6UW68; -.
DR SwissPalm; Q6UW68; -.
DR BioMuta; TMEM205; -.
DR DMDM; 74749383; -.
DR EPD; Q6UW68; -.
DR jPOST; Q6UW68; -.
DR MassIVE; Q6UW68; -.
DR MaxQB; Q6UW68; -.
DR PaxDb; Q6UW68; -.
DR PeptideAtlas; Q6UW68; -.
DR PRIDE; Q6UW68; -.
DR ProteomicsDB; 67453; -.
DR TopDownProteomics; Q6UW68; -.
DR Antibodypedia; 52091; 115 antibodies from 24 providers.
DR DNASU; 374882; -.
DR Ensembl; ENST00000354882.10; ENSP00000346954.4; ENSG00000105518.14.
DR Ensembl; ENST00000447337.5; ENSP00000398258.1; ENSG00000105518.14.
DR Ensembl; ENST00000586590.5; ENSP00000466986.1; ENSG00000105518.14.
DR Ensembl; ENST00000586956.5; ENSP00000465483.1; ENSG00000105518.14.
DR Ensembl; ENST00000587948.5; ENSP00000465149.1; ENSG00000105518.14.
DR Ensembl; ENST00000588560.5; ENSP00000466495.1; ENSG00000105518.14.
DR Ensembl; ENST00000589555.5; ENSP00000465553.1; ENSG00000105518.14.
DR Ensembl; ENST00000593256.6; ENSP00000468733.1; ENSG00000105518.14.
DR GeneID; 374882; -.
DR KEGG; hsa:374882; -.
DR MANE-Select; ENST00000354882.10; ENSP00000346954.4; NM_198536.3; NP_940938.1.
DR UCSC; uc002mqz.3; human.
DR CTD; 374882; -.
DR DisGeNET; 374882; -.
DR GeneCards; TMEM205; -.
DR HGNC; HGNC:29631; TMEM205.
DR HPA; ENSG00000105518; Low tissue specificity.
DR MIM; 613771; gene.
DR neXtProt; NX_Q6UW68; -.
DR OpenTargets; ENSG00000105518; -.
DR PharmGKB; PA162406385; -.
DR VEuPathDB; HostDB:ENSG00000105518; -.
DR eggNOG; KOG2886; Eukaryota.
DR GeneTree; ENSGT00390000016298; -.
DR InParanoid; Q6UW68; -.
DR OMA; FQMRAVE; -.
DR OrthoDB; 1785664at2759; -.
DR PhylomeDB; Q6UW68; -.
DR TreeFam; TF323838; -.
DR PathwayCommons; Q6UW68; -.
DR SignaLink; Q6UW68; -.
DR BioGRID-ORCS; 374882; 12 hits in 1081 CRISPR screens.
DR ChiTaRS; TMEM205; human.
DR GenomeRNAi; 374882; -.
DR Pharos; Q6UW68; Tdark.
DR PRO; PR:Q6UW68; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q6UW68; protein.
DR Bgee; ENSG00000105518; Expressed in left adrenal gland cortex and 176 other tissues.
DR ExpressionAtlas; Q6UW68; baseline and differential.
DR Genevisible; Q6UW68; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR025423; DUF4149.
DR InterPro; IPR042623; TMEM205.
DR PANTHER; PTHR46916; PTHR46916; 1.
DR Pfam; PF13664; DUF4149; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..189
FT /note="Transmembrane protein 205"
FT /id="PRO_0000317501"
FT TRANSMEM 18..38
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..186
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 189 AA; 21198 MW; FCC1C48C5B1601B5 CRC64;
MEEGGNLGGL IKMVHLLVLS GAWGMQMWVT FVSGFLLFRS LPRHTFGLVQ SKLFPFYFHI
SMGCAFINLC ILASQHAWAQ LTFWEASQLY LLFLSLTLAT VNARWLEPRT TAAMWALQTV
EKERGLGGEV PGSHQGPDPY RQLREKDPKY SALRQNFFRY HGLSSLCNLG CVLSNGLCLA
GLALEIRSL
