ID   TM205_MOUSE             Reviewed;         189 AA.
AC   Q91XE8; Q9JME6;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Transmembrane protein 205;
GN   Name=Tmem205;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=10679242; DOI=10.1006/bbrc.2000.2170;
RA   Inoue S., Sano H., Ohta M.;
RT   "Growth suppression of Escherichia coli by induction of expression of
RT   mammalian genes with transmembrane or ATPase domains.";
RL   Biochem. Biophys. Res. Commun. 268:553-561(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brown adipose tissue, Kidney, Liver, Lung, Pancreas, Spleen, and
RC   Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMEM205 family. {ECO:0000305}.
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DR   EMBL; AB030201; BAA92764.1; -; mRNA.
DR   EMBL; BC010787; AAH10787.1; -; mRNA.
DR   CCDS; CCDS22913.1; -.
DR   RefSeq; NP_001240797.1; NM_001253868.1.
DR   RefSeq; NP_001240798.1; NM_001253869.1.
DR   RefSeq; NP_001240799.1; NM_001253870.1.
DR   RefSeq; NP_848692.2; NM_178577.5.
DR   AlphaFoldDB; Q91XE8; -.
DR   STRING; 10090.ENSMUSP00000137301; -.
DR   iPTMnet; Q91XE8; -.
DR   PhosphoSitePlus; Q91XE8; -.
DR   EPD; Q91XE8; -.
DR   jPOST; Q91XE8; -.
DR   MaxQB; Q91XE8; -.
DR   PaxDb; Q91XE8; -.
DR   PeptideAtlas; Q91XE8; -.
DR   PRIDE; Q91XE8; -.
DR   ProteomicsDB; 258912; -.
DR   Antibodypedia; 52091; 115 antibodies from 24 providers.
DR   DNASU; 235043; -.
DR   Ensembl; ENSMUST00000046831; ENSMUSP00000048832; ENSMUSG00000040883.
DR   Ensembl; ENSMUST00000213698; ENSMUSP00000150045; ENSMUSG00000040883.
DR   Ensembl; ENSMUST00000238930; ENSMUSP00000158874; ENSMUSG00000040883.
DR   GeneID; 235043; -.
DR   KEGG; mmu:235043; -.
DR   UCSC; uc009omw.2; mouse.
DR   CTD; 374882; -.
DR   MGI; MGI:3045495; Tmem205.
DR   VEuPathDB; HostDB:ENSMUSG00000040883; -.
DR   eggNOG; KOG2886; Eukaryota.
DR   GeneTree; ENSGT00390000016298; -.
DR   HOGENOM; CLU_094297_1_1_1; -.
DR   InParanoid; Q91XE8; -.
DR   OMA; FQMRAVE; -.
DR   OrthoDB; 1173611at2759; -.
DR   PhylomeDB; Q91XE8; -.
DR   TreeFam; TF323838; -.
DR   BioGRID-ORCS; 235043; 2 hits in 74 CRISPR screens.
DR   PRO; PR:Q91XE8; -.
DR   Proteomes; UP000000589; Chromosome 9.
DR   RNAct; Q91XE8; protein.
DR   Bgee; ENSMUSG00000040883; Expressed in left lobe of liver and 223 other tissues.
DR   ExpressionAtlas; Q91XE8; baseline and differential.
DR   Genevisible; Q91XE8; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR025423; DUF4149.
DR   InterPro; IPR042623; TMEM205.
DR   PANTHER; PTHR46916; PTHR46916; 1.
DR   Pfam; PF13664; DUF4149; 1.
PE   1: Evidence at protein level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..189
FT                   /note="Transmembrane protein 205"
FT                   /id="PRO_0000317502"
FT   TRANSMEM        18..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        166..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        37
FT                   /note="L -> F (in Ref. 1; BAA92764)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   189 AA;  21180 MW;  675310A2342013E2 CRC64;
     MEKGEDPGSL IKVIHLLVLS GAWGMQVWVT FISGFLLFRS LPRHTFGLVQ SKVFPVYFHV
     SLGCAFINLC ILAPQRAWIH LTLWEVSQLS LLLLSLTLAT INARWLEART TAVMRALQSI
     EKERGLGTEV PGNFQGPDPY RQLRDKDPKY SALRRKFYHY HGLSSLCNLG CLLSNGLCLV
     GLALGLRSL