TM207_HUMAN
ID TM207_HUMAN Reviewed; 146 AA.
AC Q6UWW9;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Transmembrane protein 207;
DE Flags: Precursor;
GN Name=TMEM207; ORFNames=UNQ846/PRO1784;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP INTERACTION WITH WWOX, TISSUE SPECIFICITY, AND MUTAGENESIS OF
RP 136-PRO-PRO-137.
RX PubMed=22226915; DOI=10.1093/carcin/bgs001;
RA Takeuchi T., Adachi Y., Nagayama T.;
RT "A WWOX-binding molecule, transmembrane protein 207, is related to the
RT invasiveness of gastric signet-ring cell carcinoma.";
RL Carcinogenesis 33:548-554(2012).
CC -!- SUBUNIT: Interacts with WWOX. {ECO:0000269|PubMed:22226915}.
CC -!- INTERACTION:
CC Q6UWW9; Q8WWA0: ITLN1; NbExp=2; IntAct=EBI-13301303, EBI-16163679;
CC Q6UWW9; Q8N5M9: JAGN1; NbExp=3; IntAct=EBI-13301303, EBI-10266796;
CC Q6UWW9; P21145: MAL; NbExp=3; IntAct=EBI-13301303, EBI-3932027;
CC Q6UWW9; Q99735: MGST2; NbExp=3; IntAct=EBI-13301303, EBI-11324706;
CC Q6UWW9; Q8N912: NRAC; NbExp=3; IntAct=EBI-13301303, EBI-12051377;
CC Q6UWW9; P42857: NSG1; NbExp=3; IntAct=EBI-13301303, EBI-6380741;
CC Q6UWW9; P57086: SCAND1; NbExp=3; IntAct=EBI-13301303, EBI-745846;
CC Q6UWW9; Q9NV12: TMEM140; NbExp=3; IntAct=EBI-13301303, EBI-2844246;
CC Q6UWW9; A2RU14: TMEM218; NbExp=3; IntAct=EBI-13301303, EBI-10173151;
CC Q6UWW9; Q9NSU2-1: TREX1; NbExp=3; IntAct=EBI-13301303, EBI-16746122;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in some signet-ring cell carcinoma,
CC especially those showing high invasion and metastatic activity (at
CC protein level). {ECO:0000269|PubMed:22226915}.
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DR EMBL; AY358607; AAQ88970.1; -; mRNA.
DR EMBL; CH471052; EAW78105.1; -; Genomic_DNA.
DR EMBL; BC071780; AAH71780.1; -; mRNA.
DR CCDS; CCDS3297.1; -.
DR RefSeq; NP_997199.1; NM_207316.2.
DR AlphaFoldDB; Q6UWW9; -.
DR BioGRID; 126299; 11.
DR IntAct; Q6UWW9; 10.
DR STRING; 9606.ENSP00000346981; -.
DR iPTMnet; Q6UWW9; -.
DR PhosphoSitePlus; Q6UWW9; -.
DR BioMuta; TMEM207; -.
DR DMDM; 74738156; -.
DR MassIVE; Q6UWW9; -.
DR PaxDb; Q6UWW9; -.
DR PeptideAtlas; Q6UWW9; -.
DR PRIDE; Q6UWW9; -.
DR Antibodypedia; 3068; 38 antibodies from 11 providers.
DR DNASU; 131920; -.
DR Ensembl; ENST00000354905.3; ENSP00000346981.2; ENSG00000198398.3.
DR GeneID; 131920; -.
DR KEGG; hsa:131920; -.
DR MANE-Select; ENST00000354905.3; ENSP00000346981.2; NM_207316.3; NP_997199.1.
DR UCSC; uc003fsj.4; human.
DR CTD; 131920; -.
DR DisGeNET; 131920; -.
DR GeneCards; TMEM207; -.
DR HGNC; HGNC:33705; TMEM207.
DR HPA; ENSG00000198398; Tissue enriched (kidney).
DR MIM; 614786; gene.
DR neXtProt; NX_Q6UWW9; -.
DR OpenTargets; ENSG00000198398; -.
DR PharmGKB; PA162406407; -.
DR VEuPathDB; HostDB:ENSG00000198398; -.
DR eggNOG; ENOG502STQD; Eukaryota.
DR GeneTree; ENSGT00390000006126; -.
DR HOGENOM; CLU_149421_0_0_1; -.
DR InParanoid; Q6UWW9; -.
DR OMA; SPTVGIH; -.
DR OrthoDB; 1447750at2759; -.
DR PhylomeDB; Q6UWW9; -.
DR TreeFam; TF342774; -.
DR PathwayCommons; Q6UWW9; -.
DR SignaLink; Q6UWW9; -.
DR BioGRID-ORCS; 131920; 4 hits in 1055 CRISPR screens.
DR GenomeRNAi; 131920; -.
DR Pharos; Q6UWW9; Tdark.
DR PRO; PR:Q6UWW9; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q6UWW9; protein.
DR Bgee; ENSG00000198398; Expressed in kidney epithelium and 10 other tissues.
DR Genevisible; Q6UWW9; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR039490; TMEM207.
DR PANTHER; PTHR36467; PTHR36467; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..146
FT /note="Transmembrane protein 207"
FT /id="PRO_0000317525"
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 57
FT /note="L -> V (in dbSNP:rs35161724)"
FT /id="VAR_051436"
FT MUTAGEN 136..137
FT /note="PP->RS: Loss of WWOX-binding."
FT /evidence="ECO:0000269|PubMed:22226915"
SQ SEQUENCE 146 AA; 16116 MW; 1FAB4346037B6DAE CRC64;
MSRSRLFSVT SAISTIGILC LPLFQLVLSD LPCEEDEMCV NYNDQHPNGW YIWILLLLVL
VAALLCGAVV LCLQCWLRRP RIDSHRRTMA VFAVGDLDSI YGTEAAVSPT VGIHLQTQTP
DLYPVPAPCF GPLGSPPPYE EIVKTT
