ID   TM208_BOVIN             Reviewed;         173 AA.
AC   Q3SZZ5;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Transmembrane protein 208;
GN   Name=TMEM208;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May function as a negative regulator of endoplasmic
CC       reticulum-stress induced autophagy. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TMEM208 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC102636; AAI02637.1; -; mRNA.
DR   RefSeq; NP_001029457.1; NM_001034285.2.
DR   AlphaFoldDB; Q3SZZ5; -.
DR   STRING; 9913.ENSBTAP00000003002; -.
DR   PaxDb; Q3SZZ5; -.
DR   Ensembl; ENSBTAT00000003002; ENSBTAP00000003002; ENSBTAG00000002327.
DR   GeneID; 507222; -.
DR   KEGG; bta:507222; -.
DR   CTD; 29100; -.
DR   VEuPathDB; HostDB:ENSBTAG00000002327; -.
DR   VGNC; VGNC:36030; TMEM208.
DR   eggNOG; KOG3269; Eukaryota.
DR   GeneTree; ENSGT00390000008139; -.
DR   HOGENOM; CLU_094308_3_0_1; -.
DR   InParanoid; Q3SZZ5; -.
DR   OMA; VFMHILA; -.
DR   OrthoDB; 1407446at2759; -.
DR   TreeFam; TF318118; -.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000002327; Expressed in rumen papilla and 109 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005773; C:vacuole; IEA:GOC.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0006624; P:vacuolar protein processing; IBA:GO_Central.
DR   InterPro; IPR008506; SND2/TMEM208.
DR   PANTHER; PTHR13505; PTHR13505; 1.
DR   Pfam; PF05620; TMEM208_SND2; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Autophagy; Endoplasmic reticulum; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..173
FT                   /note="Transmembrane protein 208"
FT                   /id="PRO_0000325966"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        51..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..129
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          153..173
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BTX3"
SQ   SEQUENCE   173 AA;  19592 MW;  9EDA05CD7706AAA5 CRC64;
     MAPKGKVGTR GKKQIFEENK ETLKFYLRII LGANAIYCLV TLVVFYSSAS FWAWMALLFS
     LAVYGASYHS MSSMARAAFS EDGALVDGGM DLNMEQGMAE HLKDVILLTA IVQVLSCFSL
     YIWSFWLLAP GRALYLLWVN VLGPWFTADS GAPAPEHNEK RQRRQERRQM KRL