ID   TM208_CHICK             Reviewed;         179 AA.
AC   Q5ZK32;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Transmembrane protein 208;
GN   Name=TMEM208; ORFNames=RCJMB04_13i12;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: May function as a negative regulator of endoplasmic
CC       reticulum-stress induced autophagy. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TMEM208 family. {ECO:0000305}.
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DR   EMBL; AJ720252; CAG31911.1; -; mRNA.
DR   AlphaFoldDB; Q5ZK32; -.
DR   PaxDb; Q5ZK32; -.
DR   VEuPathDB; HostDB:geneid_100857564; -.
DR   InParanoid; Q5ZK32; -.
DR   PhylomeDB; Q5ZK32; -.
DR   PRO; PR:Q5ZK32; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005773; C:vacuole; IEA:GOC.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0006624; P:vacuolar protein processing; IBA:GO_Central.
DR   InterPro; IPR008506; SND2/TMEM208.
DR   PANTHER; PTHR13505; PTHR13505; 1.
DR   Pfam; PF05620; TMEM208_SND2; 1.
PE   2: Evidence at transcript level;
KW   Autophagy; Endoplasmic reticulum; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..179
FT                   /note="Transmembrane protein 208"
FT                   /id="PRO_0000325969"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        51..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          159..179
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        165..179
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   179 AA;  19967 MW;  82CE426B6B45CF5F CRC64;
     MAPKGKAGTK GKKQIFEENR ETLRFYLRII LGASAVYAAV NLVVFYPAAS AWTWLAFAFS
     SAVYGASYRS MSSMARPAFA DDGSLADGGI DLNMEQGWQS ECPHPHEPRH LKDVILLTAM
     VQVLSCFSLY VWYFWLLAPG RALYLLWVNI LGPWFTAESS APGQEPNEKK QRRTGTPPE