ID   TM208_DANRE             Reviewed;         175 AA.
AC   Q6NYP0;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Transmembrane protein 208;
GN   Name=tmem208; ORFNames=zgc:77041;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney, and Ovary;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May function as a negative regulator of endoplasmic
CC       reticulum-stress induced autophagy. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TMEM208 family. {ECO:0000305}.
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DR   EMBL; BC066516; AAH66516.1; -; mRNA.
DR   EMBL; BC124418; AAI24419.1; -; mRNA.
DR   RefSeq; NP_996983.1; NM_207100.2.
DR   AlphaFoldDB; Q6NYP0; -.
DR   STRING; 7955.ENSDARP00000089483; -.
DR   PaxDb; Q6NYP0; -.
DR   Ensembl; ENSDART00000098712; ENSDARP00000089483; ENSDARG00000068291.
DR   GeneID; 404632; -.
DR   KEGG; dre:404632; -.
DR   CTD; 29100; -.
DR   ZFIN; ZDB-GENE-040426-2523; tmem208.
DR   eggNOG; KOG3269; Eukaryota.
DR   GeneTree; ENSGT00390000008139; -.
DR   HOGENOM; CLU_094308_3_0_1; -.
DR   InParanoid; Q6NYP0; -.
DR   OMA; VFMHILA; -.
DR   OrthoDB; 1407446at2759; -.
DR   PhylomeDB; Q6NYP0; -.
DR   TreeFam; TF318118; -.
DR   PRO; PR:Q6NYP0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 7.
DR   Bgee; ENSDARG00000068291; Expressed in liver and 27 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005773; C:vacuole; IEA:GOC.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0006624; P:vacuolar protein processing; IBA:GO_Central.
DR   InterPro; IPR008506; SND2/TMEM208.
DR   PANTHER; PTHR13505; PTHR13505; 1.
DR   Pfam; PF05620; TMEM208_SND2; 1.
PE   2: Evidence at transcript level;
KW   Autophagy; Endoplasmic reticulum; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..175
FT                   /note="Transmembrane protein 208"
FT                   /id="PRO_0000325970"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        51..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          152..175
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   175 AA;  20034 MW;  8B3A1CA34EB86F57 CRC64;
     MAPKGKVGTK GKKQIHEENQ DTLKFYSRII LGANAIYIAV NLLLFYNSSS FWTWFSLMFA
     VAVYVGSYRS MSAMAKPAFA EDGSLLDGGI DLNMEQGMAE HLKDVILLTA IVQVLSTLSS
     YFWYLWLLAP ARALHLLWVN FLGPWFSADS QAAPEENEKN DKKQRRQERR QMRRF